ArticleCerebral cortex (New York, N.Y. : 1991)2021
Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Physical exercise for prevention of dementia study: a 48-month randomized controlled trial.Frontiers in aging · 2026Trial
- Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults.Cognitive, affective & behavioral neuroscience · 2026Article
- Lifestyle and Transcriptional Signatures Associated with Ethnicity/Race-Related Variations in the Functional Connectome.Research (Washington, D.C.) · 2026Article
- Cognitive profiles among dementia-free older adults and their associations with neuroimaging markers.Brain imaging and behavior · 2025Article
- Long-term cumulative physical activity associated with less cognitive decline: Evidence from a 16-year cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Effect of DC-GVS on resting functional EEG networks in healthy people.Experimental brain research · 2025Article
- Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults.Sports medicine - open · 2024Article
- Educational Attainment Moderates Task-State Control Network Connectivity Relations to Response Conflict Among Healthy Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle-to-old aged community participants.Human brain mapping · 2024Article
- Early-life participation in cognitively stimulating activities and risk of depression and anxiety in late life.Psychological medicine · 2024Article
- Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.Scientific reports · 2023Article
- [Late-life depression and frailty-Epidemiological, clinical and neurobiological associations].Der Nervenarzt · 2023Review
- Editorial: Insights in neurocognitive aging and behavior: 2021.Frontiers in aging neuroscience · 2023Article
- Brain Functional Connectivity in Middle-Aged Hong Chuan Tai Chi Players in Resting State.International journal of environmental research and public health · 2022Article
- Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults.Neurobiology of aging · 2022Article
- Physical activity moderates the association between white matter hyperintensity burden and cognitive change.Frontiers in aging neuroscience · 2022Article
- Does cognitive aging follow an orchid and dandelion phenomenon?Frontiers in aging neuroscience · 2022Article
- Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.Frontiers in psychology · 2022Article
- Magnetoencephalography Brain Signatures Relate to Cognition and Cognitive Reserve in the Oldest-Old: The EMIF-AD 90 + Study.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
This study examines the relationship of engagement in different lifestyle activities to connectivity in large-scale functional brain networks, and whether network connectivity modifies cognitive decline, independent of brain amyloid levels. Participants (N = 153, mean age = 69 years, including N = 126 with amyloid imaging) were cognitively normal when they completed resting-state functional magnetic resonance imaging, a lifestyle activity questionnaire, and cognitive testing. They were followed with annual cognitive tests up to 5 years (mean = 3.3 years). Linear regressions showed positive relationships between cognitive activity engagement and connectivity within the dorsal attention network, and between physical activity levels and connectivity within the default-mode, limbic, and frontoparietal control networks, and global within-network connectivity. Additionally, higher cognitive and physical activity levels were independently associated with higher network modularity, a measure of functional network specialization. These associations were largely independent of APOE4 genotype, amyloid burden, global brain atrophy, vascular risk, and level of cognitive reserve. Moreover, higher connectivity in the dorsal attention, default-mode, and limbic networks, and greater global connectivity and modularity were associated with reduced cognitive decline, independent of APOE4 genotype and amyloid burden. These findings suggest that changes in functional brain connectivity may be one mechanism by which lifestyle activity engagement reduces cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.