Evidence map›Paper›PMID 34184027›Full record

ArticleDevelopment (Cambridge, England)2021

The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.

Mari Ichinose, Nobumi Suzuki, Tongtong Wang, Hiroki Kobayashi, Laura Vrbanac, Jia Q Ng, Josephine A Wright, Tamsin R M Lannagan, Krystyna A Gieniec, Martin Lewis and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Modeling cerebral developmentbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Mari IchinoseSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Nobumi SuzukiSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Tongtong WangSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Hiroki KobayashiSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Laura VrbanacSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Jia Q NgSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Josephine A WrightSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Tamsin R M LannaganSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Krystyna A GieniecSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Martin LewisDepartment of Psychiatry, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5001, Australia.ORCID 0000-0002-3332-3776
Ryota AndoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Atsushi EnomotoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Simon KoblarSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Paul ThomasSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.
Daniel L WorthleyPrecision Medicine, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Susan L WoodsSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, SA 5000, Australia.ORCID 0000-0002-8955-2017
South Australian Health and Medical Research Institute · AUNagoya University · JPFlinders University · AU

Funding

Astellas Foundation for Research on Metabolic DisordersCancer Council SA Beat Cancer Project MCF0418Cancer Council South Australia MCF0418Greaton InternationalJapan Society for the Promotion of Science 19K17478Japan Society for the Promotion of Science Overseas Research FellowshipKakenhi Grant in AidKanae Foundation for the Promotion of Medical ScienceKanzawa Medical Research FoundationNational Health and Medical Research Council APP1140236National Health and Medical Research Council CDF1Takeda Science FoundationUehara Memorial Foundation
6 · The paper itself

Abstract

Bone morphogenetic protein (BMP) signaling is required for early forebrain development and cortical formation. How the endogenous modulators of BMP signaling regulate the structural and functional maturation of the developing brain remains unclear. Here, we show that expression of the BMP antagonist Grem1 marks committed layer V and VI glutamatergic neurons in the embryonic mouse brain. Lineage tracing of Grem1-expressing cells in the embryonic brain was examined by administration of tamoxifen to pregnant Grem1creERT; Rosa26LSLTdtomato mice at 13.5 days post coitum (dpc), followed by collection of embryos later in gestation. In addition, at 14.5 dpc, bulk mRNA-seq analysis of differentially expressed transcripts between FACS-sorted Grem1-positive and -negative cells was performed. We also generated Emx1-cre-mediated Grem1 conditional knockout mice (Emx1-Cre;Grem1flox/flox) in which the Grem1 gene was deleted specifically in the dorsal telencephalon. Grem1Emx1cKO animals had reduced cortical thickness, especially layers V and VI, and impaired motor balance and fear sensitivity compared with littermate controls. This study has revealed new roles for Grem1 in the structural and functional maturation of the developing cortex.

Indexed as

Signal TransductionAnimalsBehavior, AnimalBone Morphogenetic Protein 1BrainCell DifferentiationCell ProliferationCytokinesFearFemaleGene Expression Regulation, DevelopmentalIntercellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutBone Morphogenetic Protein 1CytokinesGrem1 protein, mouseIntercellular Signaling Peptides and ProteinsBMPCortical developmentExcitatory neuronGrem1Mouse

Identifiers

PMID34184027
PMCPMC8313862
OpenAlexW3176007763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.