ArticleNature neuroscience2021
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Temporal integration in the subcortical auditory system and behavioral evidence of its dysfunction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Learning Decouples Accuracy and Reaction Time for Rapid Decisions in a Transitive Inference Task.Journal of cognitive neuroscience · 2026Article
- Selective encoding of priors for flexible categorization but not Bayesian inference in the frontal eye field.bioRxiv : the preprint server for biology · 2026Article
- Attention-related modulation in the superior colliculus encodes perceptual sensitivity, but not perceptual choice.Nature communications · 2026Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T.Frontiers in neuroscience · 2026Article
- Nonlinear feedback modulation contributes to the optimization of flexible decision-making.eLife · 2025Article
- Joint models reveal human subcortical underpinnings of choice and learning behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Physiological correlates of a simple saccadic-decision task to extended objects in superior colliculus.iScience · 2025Article
- Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making.Nature communications · 2025Article
- Spatial Processing Enhancement in the Prefrontal Cortex for Rapid Detection of Valuable Objects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effort drives saccade selection.eLife · 2025Article
- Non-decision time: The Higgs Boson of decision.Psychological review · 2025Article
- Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.Current biology : CB · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Confidence control for efficient behaviour in dynamic environments.Nature communications · 2024Article
- Primate superior colliculus is causally engaged in abstract higher-order cognition.Nature neuroscience · 2024Article
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Abstract
Trained monkeys performed a two-choice perceptual decision-making task in which they reported the perceived orientation of a dynamic Glass pattern, before and after unilateral, reversible, inactivation of a brainstem area-the superior colliculus (SC)-involved in preparing eye movements. We found that unilateral SC inactivation produced significant decision biases and changes in reaction times consistent with a causal role for the primate SC in perceptual decision-making. Fitting signal detection theory and sequential sampling models to the data showed that SC inactivation produced a decrease in the relative evidence for contralateral decisions, as if adding a constant offset to a time-varying evidence signal for the ipsilateral choice. The results provide causal evidence for an embodied cognition model of perceptual decision-making and provide compelling evidence that the SC of primates (a brainstem structure) plays a causal role in how evidence is computed for decisions-a process usually attributed to the forebrain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.