Evidence map›Paper›PMID 34183814›Full record

ArticleNature microbiology2021

Single-molecule imaging of LexA degradation in Escherichia coli elucidates regulatory mechanisms and heterogeneity of the SOS response.

Emma C Jones, Stephan Uphoff

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Microbiology spectrum · 2026
    Article
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  9. Article
  10. Diversification, niche adaptation, and evolution of a candidate phylum thriving in the deep Critical Zone.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Proteomic profiling ofTurkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  13. Review
  14. The fitness connection of antibiotic resistance.Frontiers in microbiology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. The Bro-Xre toxin-antitoxin modules inFrontiers in microbiology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emma C JonesDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0002-2321-3661
Stephan UphoffDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom. stephan.uphoff@bioch.ox.ac.uk.ORCID http://orcid.org/0000-0002-3579-0888
University of Oxford · GB

Funding

Wellcome Trust 206159Wellcome Trust 206159/Z/17/Z
6 · The paper itself

Abstract

The bacterial SOS response represents a paradigm of gene networks controlled by a master transcriptional regulator. Self-cleavage of the SOS repressor LexA induces a wide range of cell functions that are critical for survival and adaptation when bacteria experience stress conditions

Indexed as

SOS Response, GeneticsBacterial ProteinsEscherichia coliGene Expression Regulation, BacterialLexA Repressor ProteinProteolysisSerine EndopeptidasesSingle Molecule ImagingBacterial ProteinsLexA Repressor ProteinSerine Endopeptidases

Identifiers

PMID34183814
PMCPMC7611437
OpenAlexW3174903262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.