Evidence map›Paper›PMID 34183776›Full record

ArticleMucosal immunology2021

Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4

Kristen L Hoek, Michael J Greer, Kathleen G McClanahan, Ali Nazmi, M Blanca Piazuelo, Kshipra Singh, Keith T Wilson, Danyvid Olivares-Villagómez

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Effects ofFrontiers in nutrition · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. IL-21-dependent Ly6CCell death discovery · 2025
    Article
  6. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Turicibacterales protect mice from severeInfection and immunity · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kristen L HoekDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael J Greer *Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Kathleen G McClanahan *Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ali NazmiDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
M Blanca PiazueloDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kshipra SinghDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Keith T WilsonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Danyvid Olivares-VillagómezDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. danyvid.olivares-villagomez@vumc.org.ORCID http://orcid.org/0000-0002-1158-8976
Vanderbilt University Medical Center · USVanderbilt University · USVA Tennessee Valley Healthcare System · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
TRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4M
TRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4M
Spermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisR01DK128200 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2021 to 2024
$2.7M
Control of lymphocyte homeostasis by iCD8a cells and osteopontinR01DK111671 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OLIVARES-VILLAGOMEZ, DANYVID · 2017 to 2021
$1.8M
Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease ProgressionI01CX002171 · VA · VETERANS HEALTH ADMINISTRATION · PI Keith T. Wilson · 2020 to 2026
–
CSRD VA I01 CX002171NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK111671NIDDK NIH HHS R01 DK128200NIDDK NIH HHS T32 DK007673NIDDK NIH HHS U24 DK059637NIGMS NIH HHS T32 GM008554
6 · The paper itself

Abstract

CD4

Indexed as

Disease SusceptibilityAnimalsBiomarkersCD4-Positive T-LymphocytesCell DifferentiationCell TransplantationCytokinesFemaleGene Expression ProfilingGene Expression RegulationGranzymesImmune ReconstitutionImmunophenotypingInterleukin-17Intraepithelial LymphocytesLymphocyte ActivationBiomarkersCytokinesGranzymesInterleukin-17

Identifiers

PMID34183776
PMCPMC8380717
OpenAlexW3173154121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.