ArticleScientific reports2021
Early extubation with immediate non-invasive ventilation versus standard weaning in intubated patients for coronavirus disease 2019: a retrospective multicenter study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease.Critical care (London, England) · 2021Trial
- Providers Consistently Delay Extubation after Successful Spontaneous Breathing Trials: A Retrospective Cohort Study.Annals of the American Thoracic Society · 2025Article
- The COVID-19 Tracheostomy Experience at a Large Academic Medical Center in New York during the First Year.Journal of clinical medicine · 2024Article
- Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19.Respiratory care · 2023Article
- Bivalirudin vs. Enoxaparin in Intubated COVID-19 Patients: A Pilot Multicenter Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Non-Invasive Ventilation as a Therapy Option for Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Acute Cardiopulmonary Oedema in Emergency Medical Services.Journal of clinical medicine · 2022Article
- Chest X-ray Does Not Predict the Risk of Endotracheal Intubation and Escalation of Treatment in COVID-19 Patients Requiring Noninvasive Respiratory Support.Journal of clinical medicine · 2022Article
- Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study.Frontiers in medicine · 2022Article
- Comfort During Non-invasive Ventilation.Frontiers in medicine · 2022Review
- Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution.Journal of anesthesia, analgesia and critical care · 2021Review
- Extubation failure and the use of noninvasive ventilation during the weaning process in critically ill COVID-19 patients.Critical care scienceObservational
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Authors and funding
47 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients intubated for hypoxemic acute respiratory failure (ARF) related to novel coronavirus disease (COVID-19), we retrospectively compared two weaning strategies, early extubation with immediate non-invasive ventilation (NIV) versus standard weaning encompassing spontaneous breathing trial (SBT), with respect to IMV duration (primary endpoint), extubation failures and reintubations, rate of tracheostomy, intensive care unit (ICU) length of stay and mortality (additional endpoints). All COVID-19 adult patients, intubated for hypoxemic ARF and subsequently extubated, were enrolled. Patients were included in two groups, early extubation followed by immediate NIV application, and conventionally weaning after passing SBT. 121 patients were enrolled and analyzed, 66 early extubated and 55 conventionally weaned after passing an SBT. IMV duration was 9 [6-11] days in early extubated patients versus 11 [6-15] days in standard weaning group (p = 0.034). Extubation failures [12 (18.2%) vs. 25 (45.5%), p = 0.002] and reintubations [12 (18.2%) vs. 22 (40.0%) p = 0.009] were fewer in early extubation compared to the standard weaning groups, respectively. Rate of tracheostomy, ICU mortality, and ICU length of stay were no different between groups. Compared to standard weaning, early extubation followed by immediate NIV shortened IMV duration and reduced the rate of extubation failure and reintubation.
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