ArticleScientific reports2021
Risk of early-onset dementia among persons with tinnitus: a retrospective case-control study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Tinnitus-associated cognitive and psychological impairments: a comprehensive review meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Association between serum α-Klotho levels and tinnitus stratified by sex and depression: A cross-sectional study from NHANES.Medicine · 2026Article
- Association Between Tinnitus and Angina Pectoris in U.S. Adults: Evidence from NHANES 2009-2018.Audiology research · 2026Article
- Early detection of Alzheimer's disease using the MEMORIES mnemonic.Chronic diseases and translational medicine · 2025Review
- Cognitive Disorders In Acquired Sensorineural Hearing Loss, At The Ent Department Of The "Village Bondeko" Center, In Kinshasa.Neuropsychiatric disease and treatment · 2025Article
- Impact of short-term tinnitus treatment on cognitive function and neural synchronization.Frontiers in neurology · 2025Article
- Tinnitus and dementia risk: a nationwide population-based case-control study.The Journal of laryngology and otology · 2024Article
- Comparative study on structural and functional brain differences in mild cognitive impairment patients with tinnitus.Frontiers in aging neuroscience · 2024Article
- Ageing as risk factor for tinnitus and its complex interplay with hearing loss-evidence from online and NHANES data.BMC medicine · 2023Article
- Considering hearing loss as a modifiable risk factor for dementia.Expert review of neurotherapeutics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher rates of poor cognitive performance are known to prevail among persons with tinnitus in all age groups. However, no study has explored the association between tinnitus and early-onset dementia. We hypothesize that tinnitus may precede or occur concurrently with subclinical or early onset dementia in adults younger than 65 years of age. This case-control study used data from the Taiwan National Health Insurance Research Database, identifying 1308 patients with early-onset dementia (dementia diagnosed before 65 years of age) and 1308 matched controls. We used multivariable logistic regressions to estimate odds ratios (ORs) for prior tinnitus among patients with dementia versus controls. Among total 2616 sample participants, the prevalence of prior tinnitus was 18%, 21.5% among cases and 14.5% among controls (p < 0.001). Multivariable logistic regression showed and adjusted OR for prior tinnitus of 1.6 for cases versus controls (95% CI: 1.3 ~ 2.0). After adjusting for sociodemographic characteristics and medical co-morbidities, patients with early-onset dementia had a 67% higher likelihood of having prior tinnitus (OR = 1.628; 95% CI = 1.321-2.006). Our findings showed that pre-existing tinnitus was associated with a 68% increased risk of developing early-onset dementia among young and middle-aged adults. The results call for greater awareness of tinnitus as a potential harbinger of future dementia in this population.
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