Observational studyScientific reports2021
Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes.Journal of clinical medicine · 2026Review
- Exposure of endothelial cells to doxorubicin inhibits extracellular matrix production by dermal fibroblasts in a paracrine manner.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Optical coherence tomography and histological assessment of cutaneous vasculature and neural changes in long-term smokers: an exploratory study.Scientific reports · 2026Article
- Single-capillary endothelial dysfunction resolved by optoacoustic mesoscopy.Light, science & applications · 2026Article
- Effect of Circadian Blood Pressure Variations on Retinal Microvascular Structures: Optical Coherence Tomography Angiography Analysis with the Nighttime Divided into Subintervals (Retinal Dawn Pattern).Medicina (Kaunas, Lithuania) · 2025Article
- Ring-segment piezopolymer sensor optimized for cylindrical-wave detection in optical-resolution optoacoustic angiography with extended imaging depth.Biomedical optics express · 2025Article
- Megahertz dynamic optical coherence tomography of blisters in human skin.Biomedical optics express · 2025Article
- GLP-1RA and the possible skin aging.Endocrine · 2025Review
- Hierarchical Poromechanical Approach to Investigate the Impact of Mechanical Loading on Human Skin Micro-Circulation.International journal for numerical methods in biomedical engineering · 2025Article
- Characterization of microvessels in the human forehead dermis using intravascular dual perfusion and immunofluorescence staining.Scientific reports · 2025Article
- Comprehensive validation of a compact laser speckle contrast imaging system for vascular function assessment: from the laboratory to the clinic.Medical & biological engineering & computing · 2025Article
- Mechanoreceptor sensory feedback is impaired by pressure induced cutaneous ischemia on the human foot sole and can predict cutaneous microvascular reactivity.Frontiers in neuroscience · 2024Article
- Observation and density estimation of a large number of skin capillaries using wide-field portable video capillaroscopy and semantic segmentation.Journal of biomedical optics · 2023Article
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
- Integrating a pressure sensor with an OCT handheld probe to facilitate imaging of microvascular information in skin tissue beds.Biomedical optics express · 2022Article
- Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.