Evidence map›Paper›PMID 34183678›Full record

ArticleNature communications2021

Organization of the inputs and outputs of the mouse superior colliculus.

Nora L Benavidez, Michael S Bienkowski, Muye Zhu, Luis H Garcia, Marina Fayzullina, Lei Gao, Ian Bowman, Lin Gou, Neda Khanjani, Kaelan R Cotter and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

  1. Article
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  4. Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  10. Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Nora L BenavidezNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-7754-0991
Michael S BienkowskiStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8231-8893
Muye ZhuStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Luis H GarciaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marina FayzullinaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lei GaoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ian BowmanStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lin GouStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Neda KhanjaniStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kaelan R CotterStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Laura KorobkovaNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Marlene BecerraStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chunru CaoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Monica Y SongNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Bin ZhangStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Seita YamashitaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Amanda J TuganguiStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian ZinggStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kasey RoseNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Darrick LoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-5516-8607
Nicholas N FosterStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tyler BoesenStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hyun-Seung MunStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sarvia AquinoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ian R WickershamMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Giorgio A AscoliKrasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA.
Houri HintiryanStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hong-Wei DongStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. hongweid@mednet.ucla.edu.ORCID 0000-0001-9972-3177

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$64.5M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1M
Anatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9M
The Mouse Connectome Project Phase III: Assembling the global neural networks of the mouse brainR01MH094360 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI · 2012 to 2021
$7.4M
Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
Integrative approach to classifying neuronal cell types of the mouse hippocampusRF1MH114112 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI, ZHANG, LI I · 2017 to 2017
$4.2M
From Terabytes of Pixels to Intuitive Brain Networks (Administrative Supplement)U01CA198932 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI · 2015 to 2017
$1.7M
Neural Networks of the Mouse Superior ColliculusF31EY029569 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAVIDEZ, NORA LISSETT · 2018 to 2020
$135k
NCI NIH HHS U01 CA198932NEI NIH HHS F31 EY029569NIBIB NIH HHS P41 EB015922NIMH NIH HHS R01 MH094360NIMH NIH HHS RF1 MH114112NIMH NIH HHS U01 MH114829NIMH NIH HHS U19 MH114821NINDS NIH HHS R01 NS039600
6 · The paper itself

Abstract

The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical input arising from higher-order associative areas coordinate with SC sensorimotor networks to influence its outputs. Here, we construct a comprehensive map of all cortico-tectal projections and identify four collicular zones with differential cortical inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) and lateral (SC.l). Further, we delineate the distinctive brain-wide input/output organization of each collicular zone, assemble multiple parallel cortico-tecto-thalamic subnetworks, and identify the somatotopic map in the SC that displays distinguishable spatial properties from the somatotopic maps in the neocortex and basal ganglia. Finally, we characterize interactions between those cortico-tecto-thalamic and cortico-basal ganglia-thalamic subnetworks. This study provides a structural basis for understanding how SC is involved in integrating different sensory modalities, translating sensory information to motor command, and coordinating different actions in goal-directed behaviors.

Indexed as

AnimalsBasal GangliaCognitionMaleMiceMice, Inbred C57BLSuperior ColliculiVision, OcularVisual PathwaysVisual Perception

Identifiers

PMID34183678
PMCPMC8239028

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.