Evidence map›Paper›PMID 34183665›Full record

ArticleCell discovery2021

Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture.

Yanfang Lu, Miao Liu, Jennifer Yang, Sherman M Weissman, Xinghua Pan, Samuel G Katz, Siyuan Wang

Open access · goldAbstract read
In one paragraph

Article in Cell discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yanfang Lu *Department of Genetics, Yale School of Medicine, New Haven, USA.ORCID http://orcid.org/0000-0001-8656-2730
Miao Liu *Department of Genetics, Yale School of Medicine, New Haven, USA.
Jennifer YangDepartment of Genetics, Yale School of Medicine, New Haven, USA.
Sherman M WeissmanDepartment of Genetics, Yale School of Medicine, New Haven, USA.
Xinghua PanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China. PanVictor@smu.edu.cn.
Samuel G KatzDepartment of Pathology, Yale School of Medicine, New Haven, USA. Samuel.Katz@yale.edu.
Siyuan WangDepartment of Genetics, Yale School of Medicine, New Haven, USA. Siyuan.Wang@yale.edu.ORCID http://orcid.org/0000-0001-6550-4064
Yale University · USCell Technology (China) · CN

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
Cell Death Regulation by Pro-Apoptotic BOK in CardiomyocytesR01HL131793 · NHLBI · YALE UNIVERSITY · PI KATZ, SAMUEL G · 2016 to 2020
$2.3M
Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2018B030308004NHLBI NIH HHS R01 HL131793NIDDK NIH HHS P30 DK034989NIDDK NIH HHS U54 DK106857U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL131793
6 · The paper itself

Abstract

The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet a more systematic investigation into the microenvironment regulation of hematopoiesis in fetal liver is necessary. Here we investigate the spatial organization and transcriptional profile of individual cells in both wild type (WT) and Tet2

Identifiers

PMID34183665
PMCPMC8238952
OpenAlexW3174048442

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.