Evidence map›Paper›PMID 34183648›Full record

ArticleCell death & disease2021

Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells.

Camila Lopez-Crisosto, Alexis Díaz-Vegas, Pablo F Castro, Beverly A Rothermel, Roberto Bravo-Sagua, Sergio Lavandero

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 34 citations in OpenAlex.

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  10. Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression.Apoptosis : an international journal on programmed cell death · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Camila Lopez-CrisostoAdvanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0003-1055-099X
Alexis Díaz-VegasCharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, 2050, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-5227-4482
Pablo F CastroAdvanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9320-1703
Beverly A RothermelDepartment of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-9037-6703
Roberto Bravo-SaguaAdvanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0001-8873-8699
Sergio LavanderoAdvanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile. slavander@uchile.cl.ORCID http://orcid.org/0000-0003-4258-1483
Advanced Center for Chronic Diseases · CLPontificia Universidad Católica de Chile · CLThe University of Sydney · AUThe University of Texas Southwestern Medical Center · US

Funding

Elevated mitochondrial fusion and function in Down syndrome - Revision - 2R01HD101006 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2019 to 2022
$2.2M
NICHD NIH HHS R01 HD101006
6 · The paper itself

Abstract

Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows for the direct transfer of Ca

Indexed as

Adenosine TriphosphateAnti-Bacterial AgentsCalciumDoxycyclineEndoplasmic ReticulumFemaleHeLa CellsHumansKineticsMitochondriaMitochondrial ProteinsOxygen ConsumptionStress, PhysiologicalUnfolded Protein ResponseAdenosine TriphosphateAnti-Bacterial AgentsCalciumDoxycyclineMitochondrial Proteins

Identifiers

PMID34183648
PMCPMC8238934
OpenAlexW3173564305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.