Evidence map›Paper›PMID 34183643›Full record

ArticleLight, science & applications2021

Shot-noise limited, supercontinuum-based optical coherence tomography.

Shreesha Rao D S, Mikkel Jensen, Lars Grüner-Nielsen, Jesper Toft Olsen, Peter Heiduschka, Björn Kemper, Jürgen Schnekenburger, Martin Glud, Mette Mogensen, Niels Møller Israelsen and 1 more

Abstract read
In one paragraph

Article in Light, science & applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shreesha Rao D SDTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0003-2007-0930
Mikkel JensenDTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0003-1455-6782
Lars Grüner-NielsenDTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-7974-8385
Jesper Toft OlsenNKT Photonics A/S, Blokken 84, 3460, Birkerød, Denmark.
Peter HeiduschkaDepartment of Ophthalmology, University of Münster Medical Centre, Domagkstr. 15, D-48149, Münster, Germany.
Björn KemperBiomedical Technology Center of the Medical Faculty, University of Münster, Mendelstr. 17, D-48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3693-9397
Jürgen SchnekenburgerBiomedical Technology Center of the Medical Faculty, University of Münster, Mendelstr. 17, D-48149, Münster, Germany.ORCID http://orcid.org/0000-0002-0199-2908
Martin GludDepartment of Dermatology, Bisbebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark.
Mette MogensenDepartment of Dermatology, Bisbebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark.
Niels Møller IsraelsenDTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-9632-7902
Ole BangDTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark. oban@fotonik.dtu.dk.

Funding

Det Frie Forskningsråd (Danish Council for Independent Research) LOISE-4184-00532BEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 722380EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) SUPUVIR-722380Innovationsfonden (Innovation Fund Denmark) ShapeOCT-4107-00011A
6 · The paper itself

Abstract

We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection.

Identifiers

PMID34183643
PMCPMC8239030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.