Evidence map›Paper›PMID 34183640›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2021

Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial.

Jerzy P Szaflarski, Rodolphe Nenert, Jane B Allendorfer, Amber N Martin, Amy W Amara, Joseph C Griffis, Aimee Dietz, Victor W Mark, Victor W Sung, Harrison C Walker and 2 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01512264 nacompletednot on this map

Post-Stroke Aphasia and rTMS Treatment Study (PART)

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2012 to 2018Enrolled28ConditionsAphasia, StrokeArmsMagstim SuperRapid
NCT06974279 narecruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuromodulation in Post-Stroke Aphasia Using TMS

TypeinterventionalSponsorMedical College of WisconsinRan2025 to 2036Enrolled50ConditionsAphasia, Stroke, LanguageArmsPrecision TMS with SFA, Control TMS with SFA
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. tDCS and Speech Therapy in Aphasia Treatment: A Multicenter Comparative Study of Efficacy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  11. Four dimensions of individualization in brain stimulation for psychiatric disorders: context, target, dose, and timing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.Current neurology and neuroscience reports · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jerzy P SzaflarskiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Rodolphe NenertDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jane B AllendorferDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amber N MartinDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amy W AmaraDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Joseph C GriffisDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Aimee DietzDepartment of Communication Sciences and Disorders, University of Cincinnati, Cincinnati, OH, USA.
Victor W MarkDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor W SungDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Harrison C WalkerDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Xiaohua ZhouDepartment of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL, USA.
Christopher J LindsellDepartment of Biostatistics, Vanderbilt University, Nashville, TN, USA.
University of Alabama at Birmingham · USUniversity of Cincinnati · USVanderbilt University · US

Funding

Post-Stroke Aphasia and rTMS Treatment (PART) StudyR01HD068488 · NICHD · UNIVERSITY OF CINCINNATI · PI SZAFLARSKI, JERZY P · 2012 to 2016
$2.5M
NICHD NIH HHS R01 HD068488
6 · The paper itself

Abstract

BACKGROUND Research indicates intermittent theta burst stimulation (iTBS) is a potential treatment of post-stroke aphasia. MATERIAL AND METHODS In this double-blind, sham-controlled trial (NCT01512264) participants were randomized to receive 3 weeks of sham (G₀), 1 week of iTBS/2 weeks of sham (G₁), 2 weeks of iTBS/1 week of sham (G₂), or 3 weeks of iTBS (G₃). FMRI localized residual language function in the left hemisphere; iTBS was applied to the maximum fMRI activation in the residual language cortex in the left frontal lobe. FMRI and aphasia testing were conducted pre-treatment, at ≤1 week after completing treatment, and at 3 months follow-up. RESULTS 27/36 participants completed the trial. We compared G0 to each of the individual treatment group and to all iTBS treatment groups combined (G₁₋₃). In individual groups, participants gained (of moderate or large effect sizes; some significant at P<0.05) on the Boston Naming Test (BNT), the Semantic Fluency Test (SFT), and the Aphasia Quotient of the Western Aphasia Battery-Revised (WAB-R AQ). In G₁₋₃, BNT, and SFT improved immediately after treatment, while the WAB-R AQ improved at 3 months. Compared to G₀, the other groups showed greater fMRI activation in both hemispheres and non-significant increases in language lateralization to the left hemisphere. Changes in IFG connectivity were noted with iTBS, showing differences between time-points, with some of them correlating with the behavioral measures. CONCLUSIONS The results of this pilot trial support the hypothesis that iTBS applied to the ipsilesional hemisphere can improve aphasia and result in cortical plasticity.

Indexed as

AphasiaAdultAgedAged, 80 and overHumansMaleMiddle AgedPilot ProjectsStrokeTranscranial Magnetic StimulationYoung Adult

Identifiers

PMID34183640
PMCPMC8254416
OpenAlexW3165836188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.