Evidence map›Paper›PMID 34183520›Full record

ArticleCancer nursing

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer.

Komal P Singh, Kord M Kober, Brenda Ernst, Jasgit Sachdev, Melanie Brewer, Qiyun Zhu, Haiwei Gu, Michele Melisko, Steven M Paul, Bruce A Cooper and 4 more

Open access · greenAbstract read
In one paragraph

Article in Cancer nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. The role of wearable technologies in supporting physical and psychosocial health outcomes among breast cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  14. Diet Quality and Dietary Inflammatory Index Score among Women's Cancer Survivors.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Komal P SinghAuthor Affiliations: Edson College of Nursing and Health Innovation, Arizona State University, Phoenix (Drs Singh and Brewer); School of Nursing (Drs Kober, Paul, Cooper, and Miaskowski) and School of Medicine (Drs Melisko, Levine, and Miaskowski), University of California, San Francisco; Mayo Clinic Cancer Center, Phoenix, Arizona (Dr Ernst); HonorHealth Medical Group, Scottsdale, Arizona (Drs Sachdev and Brewer); Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe (Dr Zhu); College of Health Solutions, Arizona State University, Phoenix (Dr Gu); Dana Farber Cancer Institute, Boston, Massachusetts (Dr Hammer); and School of Nursing, University of Pittsburgh, Pennsylvania (Dr Conley).
Kord M Kober
Brenda Ernst
Jasgit Sachdev
Melanie Brewer
Qiyun Zhu
Haiwei Gu
Michele Melisko
Steven M Paul
Bruce A Cooper
Marilyn Hammer
Yvette P Conley
Jon D Levine
Christine Miaskowski
American Cancer Society · US

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
NCI NIH HHS R01 CA134900
6 · The paper itself

Abstract

backgroundUnrelieved chemotherapy-induced nausea (CIN) is a significant problem for patients with breast cancer (BC).

objectiveIn a sample of patients with BC who were assessed before their second or third cycle of chemotherapy, study purposes were to evaluate for the occurrence, severity, frequency, and distress associated with CIN; evaluate for differences in demographic and clinical characteristics and gastrointestinal (GI) symptom occurrence rates between patients who did and did not report CIN; and determine which demographic, clinical, and symptom characteristics were associated with the occurrence of CIN.

methodsPatients completed demographic and clinical questionnaires and the Memorial Symptom Assessment Scale for nausea and common GI symptom assessments. Univariate analyses evaluated for differences in demographic and clinical characteristics and GI symptom occurrence between patients who did and did not report CIN. Multiple logistic regression analysis evaluated for characteristics associated with CIN.

resultsOf the 532 patients with BC, 47.2% reported CIN occurrence. Characteristics associated with CIN group membership were poorer functional status, receipt of chemotherapy on a 14-day cycle, and higher occurrence rates of 5 GI symptoms (ie, dry mouth, vomiting, constipation, change in the way food tastes, and lack of appetite; all P < .001).

conclusionsUnrelieved CIN is a common symptom in patients with BC. This study is the first to demonstrate that 5 co-occurring GI symptoms were associated with CIN occurrence. IMPLICATIONS FOR PRACTICE: This study identified new risk factors for CIN occurrence in patients with BC. Clinicians may be able to initiate additional interventions to alleviate CIN.

Indexed as

Antineoplastic AgentsBreast NeoplasmsFemaleHumansNauseaSurveys and QuestionnairesVomitingAntineoplastic Agents

Identifiers

PMID34183520
PMCPMC8712622
OpenAlexW3175813320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.