ArticleHeart (British Cardiac Society)2022
Natriuretic peptide level at heart failure diagnosis and risk of hospitalisation and death in England 2004-2018.
Article in Heart (British Cardiac Society), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Conceptualising diagnostic liminality: a qualitative exploration of the journey to heart failure diagnosis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Post-COVID-19 era heart failure diagnosis and outcomes: adherence to National Institute for Health and Care Excellence Guidelines.Open heart · 2026Article
- Natriuretic peptides testing and survival prediction models for chronic heart failure: a systematic review of added prognostic value.Diagnostic and prognostic research · 2025Review
- Health inequalities and trends in heart failure diagnosis in primary care in England, 2000-21: a national retrospective cohort data-linkage study.The Lancet. Primary care · 2025Article
- NT-proBNP testing for heart failure diagnosis in people with atrial fibrillation: A diagnostic accuracy study.PLoS medicine · 2025Article
- Age-adjusted natriuretic peptide thresholds for a diagnosis of heart failure in the community: Diagnostic accuracy study.ESC heart failure · 2025Article
- Use of NT-proBNP for the screening, diagnosis and risk-stratification of left ventricular dysfunction.Diabetes, obesity & metabolism · 2025Review
- Predictive role of serum sST2 for heart failure in children with severe pneumonia.European journal of medical research · 2025Article
- Prediction of recurrent heart failure hospitalizations and mortality using the echocardiographic Killip score.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- The Impact of Metformin on BNP Levels: A Potential Cardioprotective Role in Type 2 Diabetes.Journal of clinical medicine · 2025Article
- Echocardiography reporting in heart failure with preserved ejection fraction: Delphi consensus study.Open heart · 2025Article
- Cardiac Biomarkers Predict Major Adverse Cardiac Events (MACE) in Incident Haemodialysis Patients: Results from a Global Federated Database.Biomedicines · 2025Article
- NT-proBNP for Heart Failure Screening in Primary Care in an Eastern European Country: What We Know and Proposed Steps.Epidemiologia (Basel, Switzerland) · 2025Article
- Saudi Heart Association Position Statement on NT-proBNP for Cardiovascular Risk Screening in Asymptomatic Adults With Type 2 Diabetes Mellitus.Journal of the Saudi Heart Association · 2025Article
- N-terminal pro-B-type natriuretic peptide concentrations, testing and associations with worsening heart failure events.ESC heart failure · 2024Article
- Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries.European heart journal · 2023Article
- Pathophysiology, emerging techniques for the assessment and novel treatment of aortic stenosis.Open heart · 2023Review
- Data Analysis of Impaired Renal and Cardiac Function Using a Combination of Standard Classifiers.Journal of personalized medicine · 2023Article
- Natriuretic peptide testing and heart failure diagnosis in primary care: diagnostic accuracy study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHeart failure (HF) is a malignant condition requiring urgent treatment. Guidelines recommend natriuretic peptide (NP) testing in primary care to prioritise referral for specialist diagnostic assessment. We aimed to assess association of baseline NP with hospitalisation and mortality in people with newly diagnosed HF.
methodsPopulation-based cohort study of 40 007 patients in the Clinical Practice Research Datalink in England with a new HF diagnosis (48% men, mean age 78.5 years). We used linked primary and secondary care data between 1 January 2004 and 31 December 2018 to report one-year hospitalisation and 1-year, 5-year and 10-year mortality by NP level.
results22 085 (55%) participants were hospitalised in the year following diagnosis. Adjusted odds of HF-related hospitalisation in those with a high NP (NT-proBNP >2000 pg/mL) were twofold greater (OR 2.26 95% CI 1.98 to 2.59) than a moderate NP (NT-proBNP 400-2000 pg/mL). All-cause mortality rates in the high NP group were 27%, 62% and 82% at 1, 5 and 10 years, compared with 19%, 50% and 77%, respectively, in the moderate NP group and, in a competing risks model, risk of HF-related death was 50% higher at each timepoint. Median time between NP test and HF diagnosis was 101 days (IQR 19-581).
conclusionsHigh baseline NP is associated with increased HF-related hospitalisation and poor survival. While healthcare systems remain under pressure from the impact of COVID-19, research to test novel strategies to prevent hospitalisation and improve outcomes-such as a mandatory two-week HF diagnosis pathway-is urgently needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.