ArticleBMJ open2021
Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Risks of cardiometabolic diseases in women with history of adverse pregnancy outcomes.Journal of human hypertension · 2026Review
- Epigenetic mediation may explain intergenerational associations between maternal obesogenic lifestyle and children's birth weight: findings from the NorthPop prospective birth cohort.Clinical epigenetics · 2025Article
- Early-Life Prevention of Cardiovascular-Kidney-Metabolic Syndrome: The DOHaD Perspective on Resveratrol and Short-Chain Fatty Acids.Antioxidants (Basel, Switzerland) · 2025Review
- Exploring socioeconomic status, lifestyle factors, and cardiometabolic disease outcomes in the United States: insights from a population-based cross-sectional study.BMC public health · 2024Article
- Article
- Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.European heart journal · 2024Article
- The Association between Birthweight and Use of Cardiovascular Medications: The Role of Health Behaviors.Journal of cardiovascular development and disease · 2023Article
- Birth size and the serum level of biological age markers in men.Scientific reports · 2023Article
- Body composition and physical fitness in adults born small for gestational age at term: a prospective cohort study.Scientific reports · 2023Article
- Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study.EClinicalMedicine · 2022Article
- Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and "Missing" Heritability.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the association between low birth weight (LBW) and cardiometabolic diseases (CMDs, including heart disease, stroke and type 2 diabetes mellitus) in adulthood, and to explore whether genetic, early-life environmental and healthy lifestyle factors play a role in this association.
designA population-based twin study.
settingTwins from the Swedish Twin Registry who were born in 1958 or earlier participated in the Screening Across the Lifespan Twin (SALT) study for a full-scale screening during 1998-2002 and were followed up until 2014.
participants19 779 twin individuals in Sweden with birthweight data available (mean age: 55.45 years). PRIMARY AND SECONDARY OUTCOME MEASURES: CMDs were assessed based on self-reported medical records, medication use and records from the National Patient Registry. A lifestyle index encompassing smoking status, alcohol consumption, exercise levels and Body Mass Index was derived from the SALT survey and categorised as unfavourable, intermediate or favourable. Data were analysed using generalised estimating equation (GEE) models and conditional logistic regression models.
resultsOf all participants, 3998 (20.2%) had LBW and 5335 (27.0%) had incident CMDs (mean age at onset: 63.64±13.26 years). In GEE models, the OR of any CMD was 1.39 (95% CI 1.27 to 1.52) for LBW. In conditional logistic regression models, the LBW-CMD association became non-significant (OR=1.21, 95% CI 0.94 to 1.56). The difference in ORs from the two models was statistically significant (p<0.001). In the joint effect analysis, the multiadjusted OR of CMDs was 3.47 (95% CI 2.72 to 4.43) for participants with LBW plus an unfavourable lifestyle and 1.25 (95% CI 0.96 to 1.62) for those with LBW plus a favourable lifestyle.
conclusionLBW is associated with an increased risk of adult CMDs, and genetic and early-life environmental factors may account for this association. However, a favourable lifestyle profile may modify this risk.
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