Evidence map›Paper›PMID 34183315›Full record

ArticleBMJ case reports2021

Right ventricular thrombus and pulmonary embolism after infliximab therapy for ulcerative colitis.

Jennifer Ann Ogilvie, Ahmed Iraqi, Christopher Haas, Raman Bharaj

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jennifer Ann OgilvieMedicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA jennifer.a.ogilvie@medstar.net.ORCID http://orcid.org/0000-0002-8925-1484
Ahmed IraqiMedicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.
Christopher HaasMedStar Franklin Square Medical Center, Baltimore, Maryland, USA.
Raman BharajMedicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.
Georgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infliximab, an antitumour necrosis factor alpha (TNF-alpha)agent, is a cornerstone of treatment of inflammatory bowel disease with a favourable and well-tolerated side effect profile. While the majority of side effects associated with infliximab have been well established, the pathophysiology of infliximab-associated thrombosis remains controversial and poorly defined. We present a case of a young woman with ulcerative colitis who presented with a right ventricular thrombus and bilateral pulmonary emboli after initiation of infliximab and was subsequently found to have underlying factor V Leiden and prothrombin gene mutation. Clinicians should be aware of this potential adverse event associated with anti-TNF agents, especially in individuals with predisposing prothrombotic mutations such as factor V Leiden or prothrombin gene mutation.

Indexed as

Colitis, UlcerativePulmonary EmbolismThrombosisFactor VFemaleHumansInfliximabTumor Necrosis Factor InhibitorsFactor VInfliximabTumor Necrosis Factor Inhibitorsgastrointestinal systemimmunological products and vaccinesinflammatory bowel diseasepulmonary embolismvenous thromboembolism

Identifiers

PMID34183315
PMCPMC8240566
OpenAlexW3174621517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.