ArticleMalaria journal2021
Humoral and cellular immune response to Plasmodium vivax VIR recombinant and synthetic antigens in individuals naturally exposed to P. vivax in the Republic of Korea.
Article in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
- IFN‑γ Production in Memory CD4ACS omega · 2025Article
- Population genetic analysis of Plasmodium vivax vir genes in Pakistan.Parasites, hosts and diseases · 2024Article
- Genetic diversity and natural selection analysis of VAR2CSA and vir genes: implication for vaccine development.Genomics & informatics · 2024Article
- A dot-blot ELISA preliminary evaluation using PvMSP1-42 recombinant protein as antigen for serological diagnosis of Plasmodium vivax infection in Thailand.European journal of microbiology & immunology · 2024Article
- Novel Chimeric Vaccine Candidate Development againstInternational journal of environmental research and public health · 2022Article
- Vivax Malaria and the Potential Role of the Subtelomeric MultigeneMicroorganisms · 2022Review
- Infections and Pregnancy: Effects on Maternal and Child Health.Frontiers in cellular and infection microbiology · 2022Review
- Article
- Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates.Memorias do Instituto Oswaldo Cruz · 2022Article
- Towards A Novel Multi-Epitopes Chimeric Vaccine for Simulating Strong Immune Responses and Protection againstInternational journal of environmental research and public health · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPlasmodium vivax proteins with variant interspersed repeats (VIR) are the key proteins used by the parasite to escape from the host immune system through the creation of antigenic variations. However, few studies have been done to elucidate their role as targets of immunity. Thus, this study evaluated the naturally-acquired immune response against VIR proteins in vivax malaria-infected individuals in the Republic of Korea (ROK).
methodsSeven recombinant VIR proteins and two synthetic peptides previously studied in other countries that elicited a robust immune response were used to investigate the antibody and cellular immune response in 681 P. vivax-infected people in ROK. The expression of IgM, IgG, and IgG subclasses against each VIR antigen or against PvMSP1-19 was analysed by ELISA. PvMSP1-19, known as a promising vaccine candidate of P. vivax, was used as the positive control for immune response assessment. Furthermore, the cellular immune response to VIR antigens was evaluated by in vitro proliferative assay, cellular activation assay, and cytokine detection in mononuclear cells of the P. vivax-infected population.
resultsIgM or IgG were detected in 52.4% of the population. Among all the VIR antigens, VIR25 elicited the highest humoral immune response in the whole population with IgG and IgM prevalence of 27.8% and 29.2%, respectively, while PvMSP1-19 elicited even higher prevalence (92%) of IgG in the population. As for the cellular immune response, VIR-C2, PvLP2, and PvMSP1-19 induced high cell activation and secretion of IL-2, IL-6, IL-10, and G-CSF in mononuclear cells from the P. vivax-infected population, comparable with results from PvMSP1-19. However, no significant proliferation response to these antigens was observed between the malaria-infected and healthy groups.
conclusionModerate natural acquisition of antibody and cellular responses in P. vivax-infected Korean malaria patients presented here are similar to that in other countries. It is interesting that the immune response to VIR antigens is conserved among malaria parasites in different countries, considering that VIR genes are highly polymorphic. This thus warrants further studies to elucidate molecular mechanisms by which human elicit immune response to the malaria parasite VIR antigens.
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