ArticleMicrobial cell factories2021
Enterococcus faecium PNC01 isolated from the intestinal mucosa of chicken as an alternative for antibiotics to reduce feed conversion rate in broiler chickens.
Article in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Encapsulation of probiotic Lactiplantibacillus plantarum S18 in sodium alginate: process optimization using Box-Behnken design for poultry feed application.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- An engineered Escherichia coli-ClyA-NetB outer membrane vesicle delivery system modulates jejunal microbiota in broiler chickens with necrotic enteritis.Poultry science · 2026Article
- Effects of different dietary methionine and cysteine ratios on growth performance and intestinal development of broilers from brain-gut peptide secretion perspective.Animal bioscience · 2026Article
- Prospects and challenges in using engineered lactic acid bacteria in aquaculture applications.Engineering microbiology · 2026Review
- Effects of marine-derived Enterococcus durans YQ-6 on growth performance, intestinal health and microbial community of Leizhou black ducks.Poultry science · 2026Article
- Probiotic potential ofVeterinary world · 2026Article
- Probiotic Enterococcus faecium (M74) as an alternative to antibiotics for controlling necrotic enteritis in broiler chickens.Scientific reports · 2026Article
- Physiological and Intestinal Microbiota Analyses Offer Insights into the Analysis of Differential Residual Feed Intake in Jian Carp (Animals : an open access journal from MDPI · 2026Article
- Effects of Supplemental Effective Microorganisms in Feed on the Growth, Lipid Deposition and GH-IGF-I Axis of the Blunt Snout BreamAquaculture nutrition · 2026Article
- Impact of novel probiotic strains isolated from Algerian fermented butter and green tea waste on broilers' production quality.Scientific reports · 2025Article
- Intestinal Microbiota of Commercial Laying Hens in a Cage-Free System Fed with Probiotics.Animals : an open access journal from MDPI · 2025Article
- Probiotic application to hatching egg surface supports microbiota development and acquisition in broiler embryos and hatchlings.Poultry science · 2025Article
- Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.International journal of molecular sciences · 2025Review
- Bacillus aryabhattai CKNJh11 as a promising probiotic improves growth performance and egg quality in laying hens.Scientific reports · 2025Article
- Evaluating the Effectiveness of Probiotic and Multivalent Vaccination Strategies in Mitigating Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Hybrid Challenge Model.Animals : an open access journal from MDPI · 2025Article
- The Characterization of Lactic Acid Bacteria Strains as Components of a Biopreparation for Chickens for Slaughter.Microorganisms · 2025Article
- Modulating effects of mycotoxin and oxidized oil on intestinal microbiota in broiler chickens.PloS one · 2025Article
- Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens.Journal of animal science and biotechnology · 2024Article
- Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium.BMC genomics · 2024Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe development and utilization of probiotics had many environmental benefits for replacing antibiotics in animal production. Bacteria in the intestinal mucosa have better adhesion to the host intestinal epithelial cells compared to bacteria in the intestinal contents. In this study, lactic acid bacteria were isolated from the intestinal mucosa of broiler chickens and investigated as the substitution to antibiotic in broiler production.
resultsIn addition to acid resistance, high temperature resistance, antimicrobial sensitivity tests, and intestinal epithelial cell adhesion, Enterococcus faecium PNC01 (E. faecium PNC01) was showed to be non-cytotoxic to epithelial cells. Draft genome sequence of E. faecium PNC01 predicted that it synthesized bacteriocin to perform probiotic functions and bacteriocin activity assay showed it inhibited Salmonella typhimurium from invading intestinal epithelial cells. Diet supplemented with E. faecium PNC01 increased the ileal villus height and crypt depth in broiler chickens, reduced the relative length of the cecum at day 21, and reduced the relative length of jejunum and ileum at day 42. Diet supplemented with E. faecium PNC01 increased the relative abundance of Firmicutes and Lactobacillus, decreased the relative abundance of Bacteroides in the cecal microbiota.
conclusionE. faecium PNC01 replaced antibiotics to reduce the feed conversion rate. Furthermore, E. faecium PNC01 improved intestinal morphology and altered the composition of microbiota in the cecum to reduce feed conversion rate. Thus, it can be used as an alternative for antibiotics in broiler production to avoid the adverse impact of antibiotics by altering the gut microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.