SynthesisBMC pregnancy and childbirth2021
Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses.
Synthesis in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06836843 (Evaluation of Maternal and Neonatal Outcomes Among Lebanese Women Conceived Through Assisted Reproductive Technology), which is not on this map. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Maternal and Neonatal Outcomes Among Lebanese Women Conceived Through Assisted Reproductive Technology
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Assisted Reproductive Technology as Predictor for Preeclampsia: A Systematic Review of Current Clinical Prediction Models.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- The risk for the development of hypertensive complications in oocyte donation pregnancy: a systematic review and individual participant data meta-analysis (DONOR IPD).Human reproduction update · 2026Pooled it
- Meta-analysis examining fetal sex-specific placental DNA methylation intensities and estimated cell composition post IVF.Molecular human reproduction · 2025Pooled it
- Perinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis.American journal of obstetrics and gynecology · 2024Pooled it
- Comparative study on pregnancy complications: PGT-A vs. IVF-ET with gender-specific outcomes.Frontiers in endocrinology · 2024Trial
- Article
- Donor versus partner sperm in IVF/ICSI: risk of preeclampsia and obstetric outcomes in a prospective registry-linkage study.Journal of assisted reproduction and genetics · 2026Article
- Insured Fertility Care in Japan: Can Universal Coverage Preserve a Single-Embryo-Transfer Culture?Cureus · 2026Review
- A systematic review examining the association between parity and gravidity & hypertension and blood pressure.NPJ cardiovascular health · 2026Article
- Neonatal and maternal outcomes following transfer of vitrified embryos compared with slow-frozen and fresh embryos: a retrospective study in singletons.BMC pregnancy and childbirth · 2026Article
- Large artery stiffness is elevated in women with a prior pregnancy conceived via in vitro fertilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Association of pre-pregnancy abnormal glucose metabolism and insulin resistance with assisted reproductive technology outcomes and pregnancy complications in women with PCOS: a retrospective propensity score matching study.BMC pregnancy and childbirth · 2026Article
- Assisted Reproductive Technology for Adults With Congenital and Acquired Heart Disease.JACC. Advances · 2026Article
- Temporal Patterns in Preterm Birth Subtypes and Perinatal Survival, 2000-2023: Population-Based, Repeated Cross-Sectional Time-Series.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Microsimulation reveals that medically assisted reproduction is unlikely to compensate for cohort fertility decline due to increasing maternal ages.Human reproduction (Oxford, England) · 2026Article
- Sequential Safety Surveillance of RSVpreF Vaccination During Pregnancy Early in the Postapproval Period.JAMA network open · 2026Article
- Construction and comparison of preeclampsia prediction models using logistic regression and machine learning.BMC medical informatics and decision making · 2026Article
- Review
- Secular trends in the prevalence of low birthweight infants in Japan from 1980 to 2020: a joinpoint regression analysis.Nagoya journal of medical science · 2026Article
- Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertensive disorders of pregnancy (HDP) is one of the most common pregnancy complications and causes of maternal morbidity and mortality. Assisted reproductive technology (ART) has been associated with adverse pregnancy outcomes, including HDP. However, the impact of multiple pregnancies, oocyte donation, as well as fresh and frozen embryo transfer needs to be further studied. We conducted a systematic review and meta-analyses to evaluate the association between ART and HDP or preeclampsia relative to spontaneous conception (SC).
methodsWe identified studies from EMBASE, MEDLINE, and Cochrane Library (up to April 8, 2020) and manually using structured search strategies. Cohort studies that included pregnancies after in vitro fertilization (IVF) with or without intracytoplasmic sperm fertilization (ICSI) relative to SC with HDP or preeclampsia as the outcome of interest were included. The control group was women who conceived spontaneously without ART or fertility medications. The pooled results were reported in odds ratios (OR) with 95% confidence intervals based on random effects models. Numbers needed to harm (NNH) were calculated based on absolute risk differences between exposure and control groups.
resultsEighty-five studies were included after a screening of 1879 abstracts and 283 full text articles. Compared to SC, IVF/ICSI singleton pregnancies (OR 1.70; 95% CI 1.60-1.80; I
conclusionsOur meta-analysis confirmed that IVF/ICSI pregnancies are at higher odds of HDP and preeclampsia than SC, irrespective of the plurality. The odds were especially high in frozen embryo transfer and oocyte donation pregnancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.