Evidence map›Paper›PMID 34182929›Full record

Trial reportBMC anesthesiology2021

The impact of multimodal analgesia based enhanced recovery protocol on quality of recovery after laparoscopic gynecological surgery: a randomized controlled trial.

Zhiyu Geng, Hui Bi, Dai Zhang, Changji Xiao, Han Song, Ye Feng, Xinni Cao, Xueying Li

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhiyu GengDepartment of Anesthesiology, Peking University First Hospital, Beijing, China. gengzhiyu2013@163.com.ORCID 0000-0002-4568-2944
Hui BiDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Dai ZhangDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Changji XiaoDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Han SongDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Ye FengDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Xinni CaoDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Xueying LiDepartment of Biostatics, Peking University First Hospital, Beijing, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur objective was to evaluate the impact of multimodal analgesia based enhanced recovery protocol on quality of recovery after laparoscopic gynecological surgery.

methodsOne hundred forty female patients scheduled for laparoscopic gynecological surgery were enrolled in this prospective, randomized controlled trial. Participants were randomized to receive either multimodal analgesia (Study group) or conventional opioid-based analgesia (Control group). The multimodal analgesic protocol consists of pre-operative acetaminophen and gabapentin, intra-operative flurbiprofen and ropivacaine, and post-operative acetaminophen and celecoxib. Both groups received an on-demand mode patient-controlled analgesia pump containing morphine for rescue analgesia. The primary outcome was Quality of Recovery-40 score at postoperative day (POD) 2. Secondary outcomes included numeric pain scores (NRS), opioid consumption, clinical recovery, C-reactive protein, and adverse events.

resultsOne hundred thirty-eight patients completed the study. The global QoR-40 scores at POD 2 were not significantly different between groups, although scores in the pain dimension were higher in Study group (32.1 ± 3.0 vs. 31.0 ± 3.2, P = 0.033). In the Study group, NRS pain scores, morphine consumption, and rescue analgesics in PACU (5.8% vs. 27.5%; P = 0.0006) were lower, time to ambulation [5.0 (3.3-7.0) h vs. 6.5 (5.0-14.8) h; P = 0.003] and time to bowel function recovery [14.5 (9.5-19.5) h vs.17 (13-23.5) h; P = 0.008] were shorter, C-reactive protein values at POD 2 was lower [4(3-6) ng/ml vs. 5 (3-10.5) ng/ml; P = 0.022] and patient satisfaction was higher (9.8 ± 0.5 vs. 8.8 ± 1.2, P = 0.000).

conclusionFor minimally invasive laparoscopic gynecological surgery, multimodal analgesia based enhanced recovery protocol offered better pain relief, lower opioid use, earlier ambulation, faster bowel function recovery and higher patient satisfaction, while no improvement in QoR-40 score was found.

trial registrationChiCTR1900026194 ; Date registered: Sep 26,2019.

Indexed as

AdultAgedAnalgesia, Patient-ControlledAnalgesicsAnalgesics, OpioidFemaleGynecologic Surgical ProceduresHumansLaparoscopyMiddle AgedMorphinePain MeasurementPatient SatisfactionPostoperative PainProspective StudiesRecovery of FunctionAnalgesicsAnalgesics, OpioidMorphineGynecologicalLaparoscopyMultimodal analgesiaQuality of recovery

Identifiers

PMID34182929
PMCPMC8237447
OpenAlexW3176603084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.