ArticlemBio2021
Generation of a Microsporidia Species Attribute Database and Analysis of the Extensive Ecological and Phenotypic Diversity of Microsporidia.
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- The Caenorhabditis elegans microbiome impacts microsporidia infection through nutrient limitation and spore inactivation.Nature communications · 2026Article
- Worms About Town: a citizen science project discovers microsporidian parasites of nematodes through environmental sampling.Biology open · 2026Article
- Ultrastructural insights into the polar tube invasion organelle from microsporidian parasites.Current opinion in microbiology · 2026Review
- MicrosporidiaOpen veterinary journal · 2026Article
- Identification of natural products and synthetic analogs which inhibit microsporidia spores and prevent infection.Journal of invertebrate pathology · 2026Article
- Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia.PLoS biology · 2025Article
- Small-molecule screen in C. elegans identifies benzenesulfonamides as inhibitors of microsporidia spores.npj antimicrobials and resistance · 2025Article
- Microsporidian infection of mosquito larvae changes the host-associated microbiome towards the synthesis of antimicrobial factors.Parasites & vectors · 2025Article
- Molecular Detection ofPathogens (Basel, Switzerland) · 2025Article
- Diversity-disease relationships in natural microscopic nematode communities.Royal Society open science · 2025Article
- Microsporidia infection alters C. elegans lipid levels.PloS one · 2025Article
- Microsporidia and invertebrate hosts: genome-informed taxonomy surrounding a new lineage of crayfish-infectingFungal diversity · 2024Article
- Agricultural Pest Management: The Role of Microorganisms in Biopesticides and Soil Bioremediation.Plants (Basel, Switzerland) · 2024Review
- Article
- High temperatures and low humidity promote the occurrence of microsporidians (Microsporidia) in mosquitoes (Culicidae).Parasites & vectors · 2024Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- High genetic diversity of Enterocytozoon bieneusi in minks and raccoon dogs in northern China.Parasite (Paris, France) · 2024Article
- Screening of the Pandemic Response Box identifies anti-microsporidia compounds.PLoS neglected tropical diseases · 2023Article
- Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis.G3 (Bethesda, Md.) · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsporidia are a large group of fungus-related obligate intracellular parasites. Though many microsporidia species have been identified over the past 160 years, depiction of the full diversity of this phylum is lacking. To systematically describe the characteristics of these parasites, we created a database of 1,440 species and their attributes, including the hosts they infect and spore characteristics. We find that microsporidia have been reported to infect 16 metazoan and 4 protozoan phyla, with smaller phyla being underrepresented. Most species are reported to infect only a single host, but those that are generalists are also more likely to infect a broader set of host tissues. Strikingly, polar tubes are threefold longer in species that infect tissues besides the intestine, suggesting that polar tube length is a determinant of tissue specificity. Phylogenetic analysis revealed four clades which each contain microsporidia that infect hosts from all major habitats. Although related species are more likely to infect similar hosts, we observe examples of changes in host specificity and convergent evolution. Taken together, our results show that microsporidia display vast diversity in their morphology and the hosts they infect, illustrating the flexibility of these parasites to evolve new traits.
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