ReviewPlant biotechnology journal2021
Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases.
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In one paragraph
Review in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 66 citations in OpenAlex.
- Fusion Partner and ER-Retention Signal Are Associated with Distinct Host Proteomic and Metabolic Responses During Interleukin-15 Production inPlants (Basel, Switzerland) · 2026Article
- Plant-based production and characterization of monoclonal antibodies targeting extracellular enveloped proteins of the Mpox Virus.Biotechnology reports (Amsterdam, Netherlands) · 2026Article
- Transient Expression and Immunogenicity Assessment of theVaccines · 2026Article
- Plant-derived vaccines for veterinary disease management in ruminants and swine.Biotechnology letters · 2026Review
- Rhinovirus, an Age-Old Problem Yet to be Solved: A Comprehensive Review Discussing Modern Therapeutics.Health science reports · 2025Article
- Industrial applications of Phanerochaete chrysosporium lignin-degrading enzymes: current status, production challenges, and future directions.World journal of microbiology & biotechnology · 2025Review
- Impact ofBiotech (Basel (Switzerland)) · 2025Article
- Harnessing controlled-environment systems for enhanced production of medicinal plants.Journal of experimental botany · 2025Review
- Neutralizing activity of anti-respiratory syncytial virus monoclonal antibody produced inHuman vaccines & immunotherapeutics · 2024Article
- A time series study of the association between extreme temperature and ozone on varicella incidence.Scientific reports · 2024Article
- Production of Plant Virus-Derived Hybrid Nanoparticles Decorated with Different Nanobodies.ACS nano · 2024Article
- Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus.Cell biochemistry and function · 2024Review
- Exploring recent progress of molecular farming for therapeutic and recombinant molecules in plant systems.Heliyon · 2024Review
- Plant-made pharmaceuticals.Plant biotechnology (Tokyo, Japan) · 2024Article
- High-quality chromosome-level genome assembly of Nicotiana benthamiana.Scientific data · 2024Article
- Efficient Expression of Functionally Active Aflibercept with Designed N-glycans.Antibodies (Basel, Switzerland) · 2024Article
- Plant virus-derived nanoparticles decorated with genetically encoded SARS-CoV-2 nanobodies display enhanced neutralizing activity.Plant biotechnology journal · 2024Article
- Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice.Biotechnology reports (Amsterdam, Netherlands) · 2024Article
- Multifactorial analysis of terminator performance on heterologous gene expression in Physcomitrella.Plant cell reports · 2024Article
- Anti-Inflammatory Effects of Helminth-Derived Products: Potential Applications and Challenges in Diabetes Mellitus Management.Journal of inflammation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors at 19 institutions in 10 countries.
Maria Lobato GómezDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.ORCID 0000-0002-2589-6216
Xin HuangDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Derry AlvarezDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Wenshu HeDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Can BaysalDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Changfu ZhuDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Victoria Armario-NajeraDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Amaya Blanco PereraDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Pedro Cerda BennasserDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Andera Saba-MayoralDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Guillermo Sobrino-MengualDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Ashwin VargheeseDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Rita AbranchesInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID 0000-0003-3173-3701
Isabel Alexandra AbreuInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Shanmugaraj BalamuruganPlant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.
Ralph BockMax Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0001-7502-6940
Johannes F BuyelFraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany.
Nicolau B da CunhaCentro de Análise Proteômicas e Bioquímicas de Brasília, Universidade Católica de Brasília, Brasília, Brazil.
Henry DaniellSchool of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4485-1176
Roland FallerDepartment of Chemical Engineering, University of California, Davis, Davis, CA, USA.
André FolgadoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Iyappan GowthamPlant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.
Suvi T HäkkinenIndustrial Biotechnology and Food Solutions, VTT Technical Research Centre of Finland Ltd, Espoo, Finland.
Shashi KumarInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Sathish Kumar RamalingamPlant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.ORCID 0000-0002-3145-7324
Cristiano LacorteBrazilian Agriculture Research Corporation, Embrapa Genetic Resources and Biotechnology and National Institute of Science and Technology Synthetic in Biology, Parque Estação Biológica, Brasilia, Brazil.
George P LomonossoffDepartment of Biological Chemistry, John Innes Centre, Norwich, UK.ORCID 0000-0003-0700-906X
Ines M LuísInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Julian K-C MaInstitute for Infection and Immunity, St. George's University of London, London, UK.ORCID 0000-0003-0767-0042
Karen A McDonaldDepartment of Chemical Engineering, University of California, Davis, Davis, CA, USA.
Andre MuradBrazilian Agriculture Research Corporation, Embrapa Genetic Resources and Biotechnology and National Institute of Science and Technology Synthetic in Biology, Parque Estação Biológica, Brasilia, Brazil.
Somen NandiDepartment of Chemical Engineering, University of California, Davis, Davis, CA, USA.
Barry O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute, and Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Frederick, MD, USA.
Kirsi-Marja Oksman-CaldenteyIndustrial Biotechnology and Food Solutions, VTT Technical Research Centre of Finland Ltd, Espoo, Finland.ORCID 0000-0003-2830-165X
Subramanian ParthibanPlant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.
Mathew J PaulInstitute for Infection and Immunity, St. George's University of London, London, UK.
Daniel PonndorfInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID 0000-0002-3259-6166
Elibio RechBrazilian Agriculture Research Corporation, Embrapa Genetic Resources and Biotechnology and National Institute of Science and Technology Synthetic in Biology, Parque Estação Biológica, Brasilia, Brazil.
Julio C M RodriguesBrazilian Agriculture Research Corporation, Embrapa Genetic Resources and Biotechnology and National Institute of Science and Technology Synthetic in Biology, Parque Estação Biológica, Brasilia, Brazil.
Stephanie RufMax Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Stefan SchillbergFraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany.
Jennifer SchwestkaInstitute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Priya S ShahDepartment of Chemical Engineering, University of California, Davis, Davis, CA, USA.
Rahul SinghSchool of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eva StogerInstitute of Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.ORCID 0000-0002-7651-7992
Richard M TwymanTRM Ltd, Scarborough, UK.ORCID 0000-0002-8764-3003
Inchakalody P VarghesePlant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.
Giovanni R ViannaBrazilian Agriculture Research Corporation, Embrapa Genetic Resources and Biotechnology and National Institute of Science and Technology Synthetic in Biology, Parque Estação Biológica, Brasilia, Brazil.
Gina WebsterInstitute for Infection and Immunity, St. George's University of London, London, UK.ORCID 0000-0001-9899-0855
Ruud H P WilbersLaboratory of Nematology, Plant Sciences Group, Wageningen University and Research, Wageningen, The Netherlands.ORCID 0000-0003-1149-9268
Teresa CapellDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.
Paul ChristouDepartment of Crop and Forest Sciences, University of Lleida-Agrotecnio CERCA Center, Lleida, Spain.ORCID 0000-0001-6358-7396
Universitat de Lleida · ESBharathiar University · INBrazilian Agricultural Research Corporation · BRUniversidade Nova de Lisboa · PTUniversity of California, Davis · USSt George's, University of London · GBBOKU University · ATJohn Innes Centre · GBMax Planck Institute of Molecular Plant Physiology · DEUniversity of Pennsylvania · USVTT Technical Research Centre of Finland · FIFraunhofer Institute for Molecular Biology and Applied Ecology · DEGraduate School Experimental Plant Sciences · NLInstitució Catalana de Recerca i Estudis Avançats · ESInternational Centre for Genetic Engineering and Biotechnology · INJustus-Liebig-Universität Gießen · DENational Cancer Institute · USScarborough General Hospital · GBUniversidade Católica de Brasília · BR
Funding
Molecular Targets ProgramZICBC010469 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OKEEFE, BARRY · 2009 to 2018
$31.4MIsolation of bioactive proteins from natural product extractsZIABC011472 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OKEEFE, BARRY · 2012 to 2025
$7.8MOral Therapy for Hemophilia AR01HL109442 · NHLBI · UNIVERSITY OF FLORIDA · PI DANIELL, HENRY, HERZOG, ROLAND W. · 2011 to 2015
$3.5MExpression of Human Therapeutic Proteins in Transgenic Tobacco ChloroplastsR01GM063879 · NIGMS · UNIVERSITY OF CENTRAL FLORIDA · PI DANIELL, HENRY · 2002 to 2010
$2.0MAustrian Science Fund FWF project W1224Austrian Science Fund FWF W 1224Biotechnology and Biological Sciences Research Council BB/L020955/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000166Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9794Intramural NIH HHS ZIA BC011472Intramural NIH HHS ZIC BC010469NASA NNX16AO69ANHLBI NIH HHS HHSN268201600011CNHLBI NIH HHS HHSN268201600014CNHLBI NIH HHS R01 HL109442NIGMS NIH HHS R01 GM063879
Abstract
Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause ˜17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.
Indexed as
Communicable DiseasesCOVID-19HumansPandemicsSARS-CoV-2COVID-19HIV/AIDSMolecular farmingplant-made pharmaceuticalsSARS-CoV-2
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