Evidence map›Paper›PMID 34182480›Full record

ArticleIn vivo (Athens, Greece)

Tetrandrine Enhances H

Yi-Ching Cheng, Chao-Lin Kuo, Sheng-Yao Hsu, Tzong-DER Way, Ching-Ling Cheng, Jaw-Chyun Chen, Kuo-Ching Liu, Shu-Fen Peng, Wai-Jane Ho, Fu-Shin Chueh and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Protective Effects ofBiology · 2025
    Article
  2. Article
  3. Tetrandrine Citrate Suppresses Breast CancerFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yi-Ching ChengDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Chao-Lin KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, R.O.C.
Sheng-Yao HsuDepartment of Ophthalmology, An Nan Hospital, China Medical University, Tainan, Taiwan, R.O.C.
Tzong-DER WayDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Ching-Ling ChengProgam of Digital Health Innovation, China Medical University, Taichung, Taiwan, R.O.C.
Jaw-Chyun ChenDepartment of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Kuo-Ching LiuDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C.
Shu-Fen PengDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Wai-Jane HoDepartment of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Fu-Shin ChuehDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. fushin@asia.edu.tw.
Wen-Wen HuangDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; wwhuang@mail.cmu.edu.tw.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTetrandrine, a bis-benzylisoquinoline alkaloid, induces apoptosis of many types of human cancer cell. Hydrogen peroxide (H MATERIALS AND

methodsHaCaT cells were pre-treated with and without tetrandrine for 1 h, and then treated with H

resultsPre-treatment of tetrandrine for 1 h and treatment with H

conclusionThese are the first and novel findings showing tetrandrine enhances H

Indexed as

BenzylisoquinolinesCaspasesApoptosisCell SurvivalHumansHydrogen PeroxideKeratinocytesReactive Oxygen SpeciesBenzylisoquinolinesCaspasesHydrogen PeroxideReactive Oxygen Speciestetrandrinecaspasecell apoptosisHaCaT cellshydrogen peroxideTetrandrine

Identifiers

PMID34182480
PMCPMC8286490
OpenAlexW3173276851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.