Evidence map›Paper›PMID 34182373›Full record

ArticleDrug and alcohol dependence2021

Tobacco withdrawal increases junk food intake: The role of the endogenous opioid system.

Justin J Anker, Motohiro Nakajima, Susan Raatz, Sharon Allen, Mustafa al'Absi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Justin J AnkerDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, 2450 Riverside Avenue, Minneapolis, MN, 55454, USA. Electronic address: anke0022@umn.edu.
Motohiro NakajimaDepartment of Family Medicine and Biobehavioral Health, University of Minnesota Medical School, 1035 University Drive, Duluth, MN, 55812, USA. Electronic address: mnakajim@d.umn.edu.
Susan RaatzDepartment of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA. Electronic address: raatz001@umn.edu.
Sharon AllenDepartment of Family Medicine and Community Health, University of Minnesota Medical School, 516 Delaware St. SE, Minneapolis, MN, 55455, USA. Electronic address: allen001@umn.edu.
Mustafa al'AbsiDepartment of Family Medicine and Biobehavioral Health, University of Minnesota Medical School, 1035 University Drive, Duluth, MN, 55812, USA. Electronic address: malabsi@d.umn.edu.
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Stress, Appetite, and Smoking RelapseR01DA027232 · NIDA · UNIVERSITY OF MINNESOTA · PI AL'ABSI, MUSTAFA, LEE, DUSTIN CLARK · 2010 to 2025
$4.6M
Stress Response and Opioid Dysfunction in Nicotine DependenceR01DA016351 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2003 to 2023
$4.5M
Physiological Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use OutcomesK01AA024805 · NIAAA · UNIVERSITY OF MINNESOTA · PI ANKER, JUSTIN JACK · 2017 to 2021
$726k
NIAAA NIH HHS K01 AA024805NIDA NIH HHS R01 DA016351NIDA NIH HHS R01 DA027232
6 · The paper itself

Abstract

backgroundThe aims of this study were to 1) determine whether acute nicotine withdrawal increases the intake of junk food (high in salt, fat, and sugar) and 2) assess whether the endogenous opioid system is involved in junk food intake during nicotine withdrawal using naltrexone as a pharmacological probe.

methodsSmokers were randomly assigned to 24-hr withdrawal from tobacco products (n = 42) or smoking ad libitum (n = 34). A non-smoking group (n = 29) was included. Participants completed two laboratory sessions where a placebo or 50 mg of naltrexone was administered. At the end of each session, participants were given a tray of snack items that differed in high to low energy density and dimensions of salty, sweet, and fat. Self-reported mood and withdrawal measures were collected immediately before the snacks were offered. Generalized linear and logistic models were used to assess the effects of acute smoking withdrawal, drug, and sex on the intake of snack items and self-reported measures.

resultsChoice and consumption of food items were impacted by smoking condition (withdrawal > ad lib smoking and non-smokers; p < .05), the opioid blockade (naltrexone < placebo; p < .05), and sex (male > female; p < .05). The effects were evidenced in high sweet and high fat foods. No differences were found in low sweet and fat foods.

conclusionsThese findings extend earlier studies indicating impact of tobacco use on appetite, and identify the regulatory influence of the endogenous opioid system on appetite during nicotine withdrawal.

Indexed as

Analgesics, OpioidSubstance Withdrawal SyndromeEatingHumansNaltrexoneNicotianaNicotineAnalgesics, OpioidNaltrexoneNicotineFood intakeNaltrexoneOpioid blockadeSex differenceSmokingTobacco use

Identifiers

PMID34182373
PMCPMC8297656
OpenAlexW3173942610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.