Evidence map›Paper›PMID 34182271›Full record

ReviewCurrent opinion in immunology2021

Microbiota and human allergic diseases: the company we keep.

Donata Vercelli

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. It's a Long Way to the Tap: Microbiome and DNA-Based Omics at the Core of Drinking Water Quality.International journal of environmental research and public health · 2022
    Review
  9. Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Microbiota and Ocular Diseases.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Donata VercelliDepartment of Cellular and Molecular Medicine, Arizona Center for the Biology of Complex Diseases and Asthma and Airway Disease Research Center, The University of Arizona, Tucson, AZ, USA. Electronic address: donata@arizona.edu.
University of Arizona · US

Funding

Recruitment, Data Collection & Sample Management CoreP01AI148104 · NIAID · UNIVERSITY OF ARIZONA · PI Tara F Carr, Susan Veronica Lynch · 2020 to 2026
$19.0M
Translational Approaches to Health Disparities in Lung, Sleep, and PandemicsR25HL126140 · NHLBI · UNIVERSITY OF ARIZONA · PI FRANCISCO A MORENO, JANKO Z. NIKOLICH · 2014 to 2026
$4.6M
Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure .R21AI144722 · NIAID · UNIVERSITY OF ARIZONA · PI VERCELLI, DONATA · 2019 to 2020
$443k
Interactions between Environmental Microbiome, Maternal Immunity, Neonatal Epigenome and Respiratory Microbiome Development as Determinants of Asthma In ChildhoodR21AI133765 · NIAID · UNIVERSITY OF ARIZONA · PI LYNCH, SUSAN VERONICA, VERCELLI, DONATA · 2017 to 2018
$439k
NHLBI NIH HHS R25 HL126140NIAID NIH HHS P01 AI148104NIAID NIH HHS R21 AI133765NIAID NIH HHS R21 AI144722
6 · The paper itself

Abstract

Environmental, maternal and early life microbial/immune networks program human developmental trajectories and health outcomes and strongly modify allergic disease risk. The effects of environmental microbiota are illustrated by the 'farm effect' (the protection against asthma and allergy conferred by growing up on a traditional farm) and other natural experiments in populations exposed to microbe-rich environments. The role of gut microbiome maturation in the asthma/allergy trajectory is demonstrated by the most recent farm studies, which identified microbial metabolites specifically associated with asthma protection, and studies in other cohorts, which defined dynamic microbial community profiles associated with allergic disease phenotypes. Current and future studies in germ-free mice associated with gut microbiota from human disease states are providing novel mechanistic insights into the role of microbiota in shaping immune function and allergic disease susceptibility.

Indexed as

Disease SusceptibilityMicrobiotaAge FactorsEnvironmental ExposureHost Microbial InteractionsHumansHypersensitivity

Identifiers

PMID34182271
PMCPMC8578191
OpenAlexW3174386762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.