Evidence map›Paper›PMID 34182161›Full record

ArticleThe journal of allergy and clinical immunology. In practice2021

Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis.

Vishwa Deepak, Hirsh D Komarow, Abdulaziz A Alblaihess, Melody C Carter, Dean D Metcalfe, Hydar Ali

Open access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  4. Non-IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions.The journal of allergy and clinical immunology. In practice · 2024
    Article
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  8. Recent insights into the mechanisms of anaphylaxis.Current opinion in immunology · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Vishwa DeepakDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pa.
Hirsh D KomarowMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Abdulaziz A AlblaihessDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pa; Department of Periodontics and Community Dentistry, King Saud University, College of Dentistry, Riyadh, Saudi Arabia.
Melody C CarterMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Dean D MetcalfeMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Hydar AliDepartment of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pa. Electronic address: alih@upenn.edu.
University of Pennsylvania · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell DisordersZIAAI000249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOMAROW, HIRSH D · 2009 to 2025
$16.5M
Roles of novel MRGPRX2/MrgprB2 signaling in mast cells on host defense and InflammationR01AI149487 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Hydar Ali · 2020 to 2026
$3.9M
Role of a novel human mast cell G protein coupled receptor in Allergy and InflammationR01AI124182 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Hydar Ali · 2016 to 2026
$2.5M
Novel Roles of GRK2 and beta-arrestin2 on mast cell-mediated allergy and InflammationR01AI143185 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALI, HYDAR · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI124182NIAID NIH HHS R01 AI143185NIAID NIH HHS R01 AI149487
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MastocytosisMastocytosis, CutaneousUrticaria PigmentosaHumansMast CellsNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, NeuropeptideSkinMRGPRX2 protein, humanNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, Neuropeptide

Identifiers

PMID34182161
PMCPMC8511159
OpenAlexW3177493777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.