Evidence map›Paper›PMID 34182141›Full record

ReviewSeminars in cancer biology2022

Virus-inspired strategies for cancer therapy.

Xiao Yin Ma, Brett D Hill, Trang Hoang, Fei Wen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cancer biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Current status and research progress of oncolytic virus.Pharmaceutical science advances · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao Yin MaDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, United States.
Brett D HillDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, United States.
Trang HoangDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, United States.
Fei WenDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: feiwenum@umich.edu.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Cytometry by Time of Fight (CyTOF) for High-speed Single-cell AnalysisS10OD020053 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEN, FEI · 2016 to 2016
$600k
NCI NIH HHS P30 CA046592NIH HHS S10 OD020053
6 · The paper itself

Abstract

The intentional use of viruses for cancer therapy dates back over a century. As viruses are inherently immunogenic and naturally optimized delivery vehicles, repurposing viruses for drug delivery, tumor antigen presentation, or selective replication in cancer cells represents a simple and elegant approach to cancer treatment. While early virotherapy was fraught with harsh side effects and low response rates, virus-based therapies have recently seen a resurgence due to newfound abilities to engineer and tune oncolytic viruses, virus-like particles, and virus-mimicking nanoparticles for improved safety and efficacy. However, despite their great potential, very few virus-based therapies have made it through clinical trials. In this review, we present an overview of virus-inspired approaches for cancer therapy, discuss engineering strategies to enhance their mechanisms of action, and highlight their application for overcoming the challenges of traditional cancer therapies.

Indexed as

NanoparticlesNeoplasmsOncolytic VirotherapyOncolytic VirusesHumansImmunotherapyCancerDrug deliveryGene therapyImmunotherapyNanomedicineOncolytic virusesVirus-like particlesVirus-mimicking nanoparticles

Identifiers

PMID34182141
PMCPMC8710185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.