Evidence map›Paper›PMID 34181866›Full record

ArticleAnnals of the American Thoracic Society2022

Parenteral Prostanoids in Pediatric Pulmonary Arterial Hypertension: Start Early, Dose High, Combine.

Johannes M Douwes, Willemijn M H Zijlstra, Erika B Rosenzweig, Mark-Jan Ploegstra, Usha S Krishnan, Meindina G Haarman, Marcus T R Roofthooft, Douwe Postmus, Hans L Hillege, D Dunbar Ivy and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Annals of the American Thoracic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Parenteral treprostinil in paediatric pulmonary arterial hypertension: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Pulmonary Hypertension in Children.Clinics in chest medicine · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Johannes M DouwesCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.ORCID 0000-0003-3146-5831
Willemijn M H ZijlstraCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.
Erika B RosenzweigCollege of Physicians and Surgeons, Columbia University, New York, New York; and.
Mark-Jan PloegstraCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.
Usha S KrishnanCollege of Physicians and Surgeons, Columbia University, New York, New York; and.
Meindina G HaarmanCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.
Marcus T R RoofthooftCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.
Douwe PostmusDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Hans L HillegeDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
D Dunbar IvyUniversity of Colorado, Children's Hospital Colorado, Aurora, Colorado.
Rolf M F BergerCenter for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, and.ORCID 0000-0002-4385-5784
Beatrix Kinderziekenhuis · NLColumbia University · USUniversity Medical Center Groningen · NLChildren's Hospital Colorado · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
NCATS NIH HHS UL1 TR002535
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypertension, PulmonaryPulmonary Arterial HypertensionAntihypertensive AgentsChildEpoprostenolHumansProstaglandinsRetrospective StudiesTreatment OutcomeAntihypertensive AgentsEpoprostenolProstaglandinscongenital heart diseaseoutcomepediatricsprostacyclinpulmonary hypertension

Identifiers

PMID34181866
PMCPMC8867364
OpenAlexW3174610345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.