Evidence map›Paper›PMID 34181859›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.

Sabine Wronski, Soren Beinke, Helena Obernolte, Nikolai N Belyaev, Ken A Saunders, Mark G Lennon, Dirk Schaudien, Peter Braubach, Danny Jonigk, Gregor Warnecke and 6 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Remember the Airway Smooth Muscle! How Rhinovirus Impairs Bronchodilator Responses.American journal of respiratory cell and molecular biology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Competitive fitness ofFrontiers in cellular and infection microbiology · 2022
    Article
  14. Human Lung Slices: New Uses for an Old Model.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Sabine WronskiFraunhofer Institute for Toxicology and Experimental Medicine, Member of Fraunhofer International Consortium for Antiinfective Research, Member of Fraunhofer Cluster of Excellence Immune-Mediated Diseases, Hannover, Germany.ORCID 0000-0002-2332-226X
Soren BeinkeResearch and Development, GlaxoSmithKline, Stevenage, United Kingdom.
Helena ObernolteFraunhofer Institute for Toxicology and Experimental Medicine, Member of Fraunhofer International Consortium for Antiinfective Research, Member of Fraunhofer Cluster of Excellence Immune-Mediated Diseases, Hannover, Germany.
Nikolai N BelyaevResearch and Development, GlaxoSmithKline, Stevenage, United Kingdom.
Ken A SaundersResearch and Development, GlaxoSmithKline, Stevenage, United Kingdom.ORCID 0000-0002-9284-1100
Mark G LennonResearch and Development, GlaxoSmithKline, Stevenage, United Kingdom.ORCID 0000-0001-7379-3302
Dirk SchaudienFraunhofer Institute for Toxicology and Experimental Medicine, Member of Fraunhofer International Consortium for Antiinfective Research, Member of Fraunhofer Cluster of Excellence Immune-Mediated Diseases, Hannover, Germany.ORCID 0000-0001-7398-7262
Peter BraubachBiomedical Research in End-Stage and Obstructive Lung Disease, Member of the German Center for Lung Research, Hannover, Germany.ORCID 0000-0003-3673-7779
Danny JonigkBiomedical Research in End-Stage and Obstructive Lung Disease, Member of the German Center for Lung Research, Hannover, Germany.ORCID 0000-0002-5251-2281
Gregor WarneckeBiomedical Research in End-Stage and Obstructive Lung Disease, Member of the German Center for Lung Research, Hannover, Germany.
Patrick ZardoDepartment of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany; and.
Hans-Gerd FieguthKlinikum Region Hannover Clinics, Hannover, Germany.
Ludwig WilkensKlinikum Region Hannover Clinics, Hannover, Germany.
Armin BraunFraunhofer Institute for Toxicology and Experimental Medicine, Member of Fraunhofer International Consortium for Antiinfective Research, Member of Fraunhofer Cluster of Excellence Immune-Mediated Diseases, Hannover, Germany.ORCID 0000-0002-1142-1463
Edith M HesselResearch and Development, GlaxoSmithKline, Stevenage, United Kingdom.
Katherina SewaldFraunhofer Institute for Toxicology and Experimental Medicine, Member of Fraunhofer International Consortium for Antiinfective Research, Member of Fraunhofer Cluster of Excellence Immune-Mediated Diseases, Hannover, Germany.
Fraunhofer Institute for Toxicology and Experimental Medicine · DEGlaxoSmithKline (United Kingdom) · GBGerman Center for Lung Research · DEKlinikum Region Hannover · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human rhinovirus (RV) is a major risk factor for chronic obstructive pulmonary disease (COPD) and asthma exacerbations. The exploration of RV pathogenesis has been hampered by a lack of disease-relevant model systems. We performed a detailed characterization of host responses to RV infection in human lung tissue

Indexed as

AgedAntiviral AgentsAsthmaBronchiEpithelial CellsFemaleGene Expression ProfilingGenome, HumanHost-Pathogen InteractionsHumansIsoxazolesLungMaleMiddle AgedPhenylalaninePicornaviridae InfectionsAntiviral AgentsIsoxazolesPhenylalaninePyrrolidinonesrupintrivirValineasthmaCOPDepithelial responsehuman lungrhinovirus

Identifiers

PMID34181859
PMCPMC8641849
OpenAlexW3175293577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.