ArticleNucleic acids research2021
Evolution of plant telomerase RNAs: farther to the past, deeper to the roots.
Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- La1: an evolutionarily conserved player in the Arabidopsis telomerase complex.Plant cell reports · 2026Article
- The Missing Piece: Functional Telomerase Restored in the Beetle Model.Genome biology and evolution · 2026Article
- Role of chromosome ends in meiotic stability, recombination and wheat evolution in the context of breeding.BMC plant biology · 2025Article
- The leaves fall, yet the tree endures.Cellular and molecular life sciences : CMLS · 2025Review
- Leishmania mexicana telomeres at high resolution: Ku80, TERT, and alternative lengthening mechanisms.BMC genomics · 2025Article
- Monkeyflower (Mimulus) uncovers the evolutionary basis of the eukaryote telomere sequence variation.PLoS genetics · 2025Article
- A degenerate telomerase RNA directs telomeric DNA synthesis in lepidopteran insects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity.The Biochemical journal · 2025Review
- Molecular and Evolutionary Analysis of RNA-Protein Interactions in Telomerase Regulation.Non-coding RNA · 2024Review
- Characterisation of the Arabidopsis thaliana telomerase TERT-TR complex.Plant molecular biology · 2024Article
- Phylogenomic insights into the first multicellular streptophyte.Current biology : CB · 2024Article
- Telomere Length Variation in Model Bryophytes.Plants (Basel, Switzerland) · 2024Article
- TeloBase: a community-curated database of telomere sequences across the tree of life.Nucleic acids research · 2024Article
- Comparative Application of Terminal Restriction Fragment Analysis Tools to Large-Scale Genomic Assays.International journal of molecular sciences · 2023Article
- No end in sight: Mysteries of the telomeric variation in plants.American journal of botany · 2023Article
- Rock, scissors, paper: How RNA structure informs function.The Plant cell · 2023Article
- Linking discoveries, mechanisms, and technologies to develop a clearer perspective on plant long noncoding RNAs.The Plant cell · 2023Review
- A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus.G3 (Bethesda, Md.) · 2023Article
- Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis.Nucleic acids research · 2023Article
- Identification of the Sequence and the Length of Telomere DNA.Methods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enormous sequence heterogeneity of telomerase RNA (TR) subunits has thus far complicated their characterization in a wider phylogenetic range. Our recent finding that land plant TRs are, similarly to known ciliate TRs, transcribed by RNA polymerase III and under the control of the type-3 promoter, allowed us to design a novel strategy to characterize TRs in early diverging Viridiplantae taxa, as well as in ciliates and other Diaphoretickes lineages. Starting with the characterization of the upstream sequence element of the type 3 promoter that is conserved in a number of small nuclear RNAs, and the expected minimum TR template region as search features, we identified candidate TRs in selected Diaphoretickes genomes. Homologous TRs were then used to build covariance models to identify TRs in more distant species. Transcripts of the identified TRs were confirmed by transcriptomic data, RT-PCR and Northern hybridization. A templating role for one of our candidates was validated in Physcomitrium patens. Analysis of secondary structure demonstrated a deep conservation of motifs (pseudoknot and template boundary element) observed in all published TRs. These results elucidate the evolution of the earliest eukaryotic TRs, linking the common origin of TRs across Diaphoretickes, and underlying evolutionary transitions in telomere repeats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.