Evidence map›Paper›PMID 34181580›Full record

Trial reportAging2021

Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1.

Tania Xu Yar Lee, Jinfu Wu, Wei-Horng Jean, Giancarlo Condello, Ahmad Alkhatib, Chao-Chieh Hsieh, Yu-Wen Hsieh, Chih-Yang Huang, Chia-Hua Kuo

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07093190 (Effect of Rg1 Supplementation on Stem Cells in Exercised Skeletal Muscles of Women > 60 y), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07093190 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Rg1 Supplementation on Stem Cells in Exercised Skeletal Muscles of Women > 60 y

TypeinterventionalSponsorUniversity of TaipeiRan2022 to 2025Enrolled11ConditionsExercise Training, Post-menopausal Women, Bone Marrow Stem Cells, Skeletal Muscle RecoveryArmsexercise following Rg1 consumption, Placebo
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
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  11. Review
  12. Review
  13. Article
  14. Ginsenosides on stem cells fate specification-a novel perspective.Frontiers in cell and developmental biology · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tania Xu Yar LeeLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Jinfu WuLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Wei-Horng JeanDepartment of Anesthesiology, Far East Memorial Hospital, New Taipei City 220, Taiwan, ROC.
Giancarlo CondelloLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Ahmad AlkhatibLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Chao-Chieh HsiehLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Yu-Wen HsiehLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan, ROC.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei City 11153, Taiwan, ROC.
University of Taipei · TWFar Eastern Memorial Hospital · TWSouth China Normal University · CNTeesside University · GBTzu Chi Foundation · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStem cell aging, characterized by elevated p16

methodsBiopsied muscles were analyzed at baseline and 24 h after squat exercise in 12 trained men (22 ± 2 y). Placebo (PLA) and immunostimulant Rg1 (5 mg) were supplemented 1 h before a squat exercise, using a double-blind counterbalanced crossover design.

resultsPerceived exertion at the end of resistance exercise session was significantly lowered after Rg1 supplementation. Exercise doubled endothelial progenitor cells (EPC) (

conclusionEPC in skeletal muscle doubled 1 d after an acute bout of resistance exercise. The exercised effects in lowering EPC aging and tissue inflammation were enhanced by immunostimulant Rg1, suggesting the involvement of immune stimulation on EPC rejuvenation.

Indexed as

Cellular SenescenceBiomarkersEndothelial Progenitor CellsExerciseGinsenosidesHumansMaleMuscle, SkeletalPeroxidaseRNA, MessengerStem CellsYoung AdultBiomarkersginsenoside Rg1GinsenosidesPeroxidaseRNA, MessengerCD4cellular senescencep16INK4aresistance exerciseRg1senolytic

Identifiers

PMID34181580
PMCPMC8266347
OpenAlexW3176938260

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.