Evidence map›Paper›PMID 34181473›Full record

ArticleAntimicrobial agents and chemotherapy2021

Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species.

Nawarat Somprasong, Jinhee Yi, Carina M Hall, Jessica R Webb, Jason W Sahl, David M Wagner, Paul Keim, Bart J Currie, Herbert P Schweizer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Guideline for antimicrobial treatment of multidrug-resistant Gram-negative infections: practice recommendations of the Brazilian Society of Infectious Diseases.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  2. Review
  3. The in vitro synergistic and antibiofilm activity of Ceftazidime/avibactam against Achromobacter species recovered from respiratory samples of cystic fibrosis patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  4. Article
  5. Antimicrobial agents and chemotherapy · 2023
    Article
  6. Crystal structures of multidrug efflux transporters fromProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nawarat SomprasongThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Jinhee YiThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Carina M HallThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Jessica R WebbGlobal and Tropical Health Division, Menzies School of Health Researchgrid.271089.5, Charles Darwin University, Darwin, Northern Territory, Australia.
Jason W SahlThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
David M WagnerThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Paul KeimThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Bart J CurrieGlobal and Tropical Health Division, Menzies School of Health Researchgrid.271089.5, Charles Darwin University, Darwin, Northern Territory, Australia.
Herbert P SchweizerThe Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Northern Arizona University · USCharles Darwin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in

Indexed as

Burkholderia cepacia complexBurkholderia pseudomalleiAnti-Bacterial AgentsCell DivisionDrug Resistance, MicrobialDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsBurkholderiamultidrug resistanceRND efflux pumps

Identifiers

PMID34181473
PMCPMC8370192
OpenAlexW3177201610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.