Evidence map›Paper›PMID 34181458›Full record

ArticleJCO global oncology2021

Development and Pilot Implementation of the Genomic Risk Assessment for Cancer Implementation and Sustainment (GRACIAS) Intervention in Mexico.

Kathleen R Blazer, Yanin Chavarri-Guerra, Cynthia Villarreal Garza, Bita Nehoray, Alejandro Mohar, Adrian Daneri-Navarro, Azucena Del Toro, Dione Aguilar, Jazmin Arteaga, Rosa Maria Álvarez and 5 more

Abstract read
In one paragraph

Article in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pathogenic variants inJournal of medicine and life · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kathleen R BlazerCity of Hope Comprehensive Cancer Center, Duarte, CA.ORCID 0000-0001-8002-7892
Yanin Chavarri-GuerraInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Cynthia Villarreal GarzaHospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, Monterrey, Mexico.ORCID 0000-0003-3587-339X
Bita NehorayCity of Hope Comprehensive Cancer Center, Duarte, CA.
Alejandro MoharInstituto Nacional de Cancerologia, Mexico City, Mexico.ORCID 0000-0002-4730-4787
Adrian Daneri-NavarroUniversidad de Guadalajara, Guadalajara, Jalisco, Mexico.ORCID 0000-0002-8206-749X
Azucena Del ToroUniversidad de Guadalajara, Guadalajara, Jalisco, Mexico.ORCID 0000-0001-5208-8903
Dione AguilarHospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, Monterrey, Mexico.ORCID 0000-0003-0491-1525
Jazmin ArteagaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.ORCID 0000-0003-3090-0299
Rosa Maria ÁlvarezInstituto Nacional de Cancerologia, Mexico City, Mexico.ORCID 0000-0002-5458-7201
Rosa MejiaCity of Hope Comprehensive Cancer Center, Duarte, CA.
Josef HerzogCity of Hope Comprehensive Cancer Center, Duarte, CA.
Danielle CastilloCity of Hope Comprehensive Cancer Center, Duarte, CA.ORCID 0000-0001-6263-148X
Maria FernandezUTHealth, The University of Texas Health Science Center at Houston, Houston, TX.
Jeffrey N WeitzelCity of Hope Comprehensive Cancer Center, Duarte, CA.ORCID 0000-0001-6714-092X

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Cancer Genetics Professional Education in a Global Community of PracticeR25CA171998 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KATHLEEN R. BLAZER · 2013 to 2026
$4.3M
Clinical Cancer Genetics Community Network: A Sustainable Research PartnershipRC4CA153828 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WEITZEL, JEFFREY N · 2010 to 2010
$1.0M
NCI NIH HHS P30 CA033572NCI NIH HHS R25 CA171998NCI NIH HHS RC4 CA153828
6 · The paper itself

Abstract

purposeGenomic cancer risk assessment (GCRA) is standard-of-care practice that uses genomic tools to identify individuals with increased cancer risk, enabling screening for early detection and cancer prevention interventions. GCRA is not available in most of Mexico, where breast cancer (BC) is the leading cause of cancer death and ovarian cancer has a high mortality rate.

methodsGuided by an implementation science framework, we piloted the Genomic Risk Assessment for Cancer Implementation and Sustainment (GRACIAS) intervention, combining GCRA training, practice support, and low-cost

resultsEleven clinicians were trained across four sites. Mean pre-post knowledge score increased from 60% to 67.2% (range 53%-86%). GCRA self-efficacy scores increased by 31% (95% CI, 6.47 to 55.54;

conclusionWe describe the first project to use implementation science methods to develop and deliver an innovative multicomponent implementation intervention, combining low-cost

Indexed as

Breast NeoplasmsGenomicsFemaleGenes, BRCA1HumansMexicoRisk Assessment

Identifiers

PMID34181458
PMCPMC8457783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.