ArticleAsian Pacific journal of cancer prevention : APJCP2021
High Prevalence of Human Papillomavirus Type 18 in Oral Potentially Malignant Disorders in Thailand.
Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- The correlation between human papillomavirus and oral lichen planus: A systematic review of the literature.Immunity, inflammation and disease · 2023Pooled it
- Evaluation of liver function test, kidney function test and hematological profile of gallbladder carcinoma in patients of Eastern Uttar Pradesh region.Discover oncology · 2026Article
- Viral Involvement in Oral Potentially Malignant Disorders: A Scoping Review.Cancer management and research · 2025Review
- The association between high-risk human papillomavirus and oral lichen planus.Clinical and experimental dental research · 2023Article
- Correlation between Oral Lichen Planus and Viral Infections Other Than HCV: A Systematic Review.Journal of clinical medicine · 2022Review
- Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Retrospective Study.Journal of pharmacy & bioallied sciences · 2022Article
- PCR-based Evaluation of Human Papillomavirus Genotypes in Oral Lichen Planus.Journal of pharmacy & bioallied sciences · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe main objectives of this study were to investigate the detection rate of high-risk human papillomavirus types 16 and 18 (high-risk HPV16/18) in oral potentially malignant disorders (OPMDs) including oral leukoplakia (OL) and oral lichen planus (OLP) in a Thai population and their associations with demographic, risk habits, and clinicopathologic features.
methodsParaffin-embedded formalin-fixed specimens from 101 OL and 59 OLP patients with patients' demographic, risk habits, and clinicopathologic data were collected. Conventional qualitative polymerase chain reaction was used to detect high-risk HPV16/18 DNA. Associations between high-risk HPV type 16/18 and demographic, clinicopathologic, risk factors (tobacco and alcohol uses) of OPMDs were analysed by Chi-square or Fisher's exact test. The results with p value less than 0.05 were considered statistically significant.
resultsHPV16/18 DNA was found in both OL and OLP groups with the detection rate of 19.8% and 18.6%, respectively. Approximately 90% of high-risk HPV were HPV18 subtype. Additionally, in OL group, high-risk HPV was found more frequently in patients with moderate/severe dysplasia than that in mild dysplasia. Interestingly, in OLP group, high-risk HPV was only detected in atrophic/ulcerative subtypes. None of risk factors was associated with high-risk HPV.
conclusionsApproximately 19% of OPMDs were HPV16/18-positive. HPV18 DNA was predominantly detected in both OL and OLP patients (90%). Additionally, the detection rate of high-risk HPV was higher in more severe dysplastic cases of OL and more clinically severe cases of OLP.
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