Evidence map›Paper›PMID 34181314›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Biomimetic Iron Complex Achieves TET Enzyme Reactivity*.

David Schmidl, Niko S W Jonasson, Eva Korytiaková, Thomas Carell, Lena J Daumann

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. A bioinorganic view on the potential chemical space of hydroxyphenylpyruvate dioxygenase-like (HPDL) enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Article
  3. Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.Angewandte Chemie (International ed. in English) · 2023
    Article
  4. Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  5. Article
  6. Spectroscopic and in vitro Investigations of FeChembiochem : a European journal of chemical biology · 2022
    Review
  7. Article
  8. Biomimetic Iron Complex Achieves TET Enzyme Reactivity*.Angewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

David SchmidlDepartment Chemie, Ludwig-Maximilians-University München, Butenandtstr. 5-13, Haus D, München, Germany.
Niko S W JonassonDepartment Chemie, Ludwig-Maximilians-University München, Butenandtstr. 5-13, Haus D, München, Germany.
Eva KorytiakováDepartment Chemie, Ludwig-Maximilians-University München, Butenandtstr. 5-13, Haus D, München, Germany.
Thomas CarellDepartment Chemie, Ludwig-Maximilians-University München, Butenandtstr. 5-13, Haus D, München, Germany.
Lena J DaumannDepartment Chemie, Ludwig-Maximilians-University München, Butenandtstr. 5-13, Haus D, München, Germany.ORCID 0000-0003-2197-136X
Ludwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epigenetic marker 5-methyl-2'-deoxycytidine (5mdC) is the most prevalent modification to DNA. It is removed inter alia via an active demethylation pathway: oxidation by Ten-Eleven Translocation 5-methyl cytosine dioxygenase (TET) and subsequent removal via base excision repair or direct demodification. Recently, we have shown that the synthetic iron(IV)-oxo complex [Fe

Indexed as

5-MethylcytosineBiomimetic MaterialsDioxygenasesIron CompoundsMolecular Conformation5-MethylcytosineDioxygenasesIron Compounds5-methyl cytosinebioinorganic chemistryDNA methylationenzyme modelsiron(IV)-oxoTET enzymes

Identifiers

PMID34181314
PMCPMC8518650
OpenAlexW3176791230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.