Trial reportTranslational stroke research2022
Carotid Plaque Vulnerability Assessed by Combined Shear Wave Elastography and Ultrafast Doppler Compared to Histology.
Trial report in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03234257 (Evaluation of the Carotid Plaque Stability by Ultrafast-ultrasound Imaging), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Carotid Plaque Stability by Ultrafast-ultrasound Imaging (UF)
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Vector Flow Imaging for Carotid Artery Stenosis Assessment: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Noninvasive Assessment of Arterial Compliance and Lumen Pressure in Human Carotid Arteries Using Physics-Informed Neural Networks and Ultrasound Imaging: A Clinical Feasibility Study.Research square · 2026Article
- Quantitative Ultrasound SWE of Carotid Plaque in Symptomatic and Asymptomatic Patients: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- A cross-sectional study: carotid artery stiffness in individuals with varying cardiovascular disease risk using shear wave elasticity.BMC cardiovascular disorders · 2026Observational
- Dual-modal ultrasound radiomics model enhances identification of symptomatic carotid plaque: a multicenter retrospective study.The international journal of cardiovascular imaging · 2026Article
- Morphological and biomechanical characteristics of carotid plaques with mild stenosis using ultrafast and high-definition ultrasonography.European radiology · 2026Article
- Assessment of Spatially-Varying Arterial Wall Stiffness and Pressure Using a Physics-Informed Neural Network and Pulse Wave Imaging: An in Silico and Experimental Phantom Study of Stenotic Vessels.Ultrasound in medicine & biology · 2026Article
- Evaluating Carotid Plaque Stiffness with Ultrasound 2D Shear-Wave Elastography in Patients Undergoing Coronary Artery Bypass Grafting.Diagnostics (Basel, Switzerland) · 2025Article
- Joint Analysis of Cardiovascular Control and Shear Wave Elastography to Determine Carotid Plaque Vulnerability.Journal of clinical medicine · 2025Article
- Intraplaque neovascularization combined with plaque elasticity for predicting ipsilateral stroke in patients with asymptomatic mild carotid stenosis.Quantitative imaging in medicine and surgery · 2024Article
- Comparing Focused-Tracked and Plane Wave-Tracked ARFI Log(VoA) In Silico and in Application to Human Carotid Atherosclerotic Plaque, Ex Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Article
- Novel ultrasound techniques in the identification of vulnerable plaques-an updated review of the literature.Frontiers in cardiovascular medicine · 2023Review
- Identification Markers of Carotid Vulnerable Plaques: An Update.Biomolecules · 2022Review
- Three-Dimensional High-Resolution Magnetic Resonance Imaging for the Assessment of Cervical Artery Dissection.Frontiers in aging neuroscience · 2022Article
- The Predictive Value of Carotid Ultrasonography With Cardiovascular Risk Factors-A "SPIDER" Promoting Atherosclerosis.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrafast ultrasound imaging (UUI) provides an estimation of carotid plaque stiffness by shear wave elastography (SWE) and the quantification of wall shear stress (WSS) by ultrafast Doppler. We aimed to evaluate the combined criteria of plaque stiffness and WSS applied on the plaque as potential biomarkers of plaque vulnerability assessed by histology. We included patients for whom carotid endarterectomy had been decided by a multidisciplinary team. UUI was performed within 48 h before surgery, and acquisitions were obtained on a carotid longitudinal view. After endarterectomy, gross examination and histological analysis were performed on each removed plaque. Forty-six plaques with SWE data and 29 with WSS data were analyzed. Histological analysis revealed 29 vulnerable and 17 stable plaques. Gray-scale median analysis by B-mode, mean, and standard deviation of stiffness by SWE did not differ between vulnerable and stable plaques. SWE analysis revealed that the percentage of stiffness range of 3-5 m/s was significantly increased in vulnerable plaques (p = 0.048). WSS alone showed no difference between stable and vulnerable plaques regardless of the segment of the plaque which was analyzed. A multiparametric score using maximal WSS at the peak of the plaque associated with SWE texture analysis parameters was calculated by stepwise regression, leading to a score with a sensitivity of 80% and a specificity of 78%. Area under the receiver operating characteristics curve was 0.85. A multiparameter scoring system including plaque stiffness and flow analysis using UUI allows to effectively identify histologically vulnerable carotid plaques. ClinicalTrials.gov Identifier: NCT03234257.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.