ArticleScience China. Life sciences2021
Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells.
Article in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A yolk sac-derived hepatic γδ T cell subpopulation develops in a hematopoietic stem cell- and thymus-independent manner.Protein & cell · 2026Article
- Single-cell transcriptomic dissection of two waves of endothelial-hematopoietic transition in a murine yolk sac.Blood science (Baltimore, Md.) · 2025Article
- Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.Nature cardiovascular research · 2025Article
- Integrative cross-species transcriptome analysis reveals earlier occurrence of myelopoiesis in pre-circulation primates compared to mice.Zoological research · 2024Article
- New insights into the endothelial origin of hematopoietic system inspired by "TIF" approaches.Blood science (Baltimore, Md.) · 2024Review
- Towards a blood ecosystem approach to dissect systemic diseases.Science China. Life sciences · 2024Article
- Identification and characterization of human hematopoietic mesoderm.Science China. Life sciences · 2024Article
- Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta-Gonad-Mesonephros Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Hematopoietic Stem Cell Development in Mammalian Embryos.Advances in experimental medicine and biology · 2023Review
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Authors and funding
10 authors.
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Abstract
During embryogenesis, hematopoietic stem progenitor cells (HSPCs) are believed to be derived from hemogenic endothelial cells (HECs). Moreover, arterial feature is proposed to be a prerequisite for HECs to generate HSPCs with lymphoid potential. Although the molecular basis of hematopoietic stem cell-competent HECs has been delicately elucidated within the embryo proper, the functional and molecular characteristics of HECs in the extraembryonic yolk sac (YS) remain largely unresolved. In this study, we initially identified six molecularly different endothelial populations in the midgestational YS through integrated analysis of several single-cell RNA sequencing (scRNA-seq) datasets and validated the arterial vasculature distribution of Gja5
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