ArticleAnnals of intensive care2021
Diaphragm dysfunction, lung aeration loss and weaning-induced pulmonary oedema in difficult-to-wean patients.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Predictive value of diaphragmatic ultrasound for weaning outcomes in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis.Critical care (London, England) · 2026Pooled it
- Risk prediction models for extubation failure in critically ill patients on mechanical ventilation: a systematic review.Frontiers in medicine · 2025Pooled it
- Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients.American journal of respiratory and critical care medicine · 2022Trial
- Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study.Critical care (London, England) · 2026Observational
- Rehabilitating the diaphragm: an integrated approach to intensive care unit-acquired dysfunction in critical illness-a narrative review.Acute and critical care · 2026Article
- Combined diaphragm and lung ultrasound profiling in healthy full-term neonates: a study of early postnatal function.European journal of pediatrics · 2026Observational
- High-flow tracheal therapy vs. tracheostomy mask in weaning: insights from a propensity-matched cohort.BMC pulmonary medicine · 2025Article
- Weaning failure from mechanical ventilation: a scoping review of the utility of ultrasonography in the weaning process.British journal of anaesthesia · 2025Article
- Thoracic fluid content by electrical cardiometry versus diaphragmatic excursion by ultrasound for the prediction of weaning success in patients with lung congestion.Acute and critical care · 2025Article
- Incidence and risk factors of weaning-induced pulmonary oedema: results from a multicentre, observational study.Critical care (London, England) · 2025Observational
- Blowing in the Wind: The Uncertain Impact of Inspiratory Muscle Strength Training in ICU Patients.American journal of respiratory and critical care medicine · 2025Article
- Value of diaphragmatic ultrasound parameters in assessing weaning outcomes and survival in ventilator-dependent intensive care unit patients.American journal of translational research · 2024Article
- Lung aeration estimated by chest electrical impedance tomography and lung ultrasound during extubation.Annals of intensive care · 2023Article
- Sonometric assessment of cough predicts extubation failure: SonoWean-a proof-of-concept study.Critical care (London, England) · 2023Article
- The increase in diaphragm thickness in preterm infants is related to birth weight: a pilot study.European journal of pediatrics · 2023Observational
- Use of thoracic ultrasound in acute respiratory distress syndrome.Annals of translational medicine · 2023Review
- Managing respiratory muscle weakness during weaning from invasive ventilation.European respiratory review : an official journal of the European Respiratory Society · 2023Article
- Observational
- Reply to Jha.American journal of respiratory and critical care medicine · 2022Article
- Respiratory distress observation scales to predict weaning outcome.Critical care (London, England) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiaphragm dysfunction and weaning-induced pulmonary oedema are commonly involved during weaning failure, but their physiological interactions have been poorly reported. Our hypothesis was that diaphragm dysfunction is not particularly associated with weaning-induced pulmonary oedema.
methodsIt was a single-centre and physiological study conducted in patients who had failed a first spontaneous breathing trial and who underwent a second trial. The diaphragm function was evaluated by measuring the tracheal pressure generated in response to a bilateral magnetic phrenic nerves stimulations. Weaning-induced pulmonary oedema was diagnosed in case of failure of the spontaneous breathing trial if patients exhibited signs of plasma concentration or echocardiographic diagnosis of pulmonary artery occlusion pressure elevation.
resultsFifty-three patients were included and 31/53 (58%) failed the spontaneous breathing trial, including 24/31 (77%) patients with weaning-induced pulmonary oedema. Diaphragm dysfunction was present in 33/53 (62%) patients. Diaphragm dysfunction or weaning-induced pulmonary oedema were present in 26/31 (84%) of the patients who failed the spontaneous breathing trial. Weaning-induced pulmonary oedema occurred in 20/33 (61%) patients with a diaphragm dysfunction and in 4/20 (20%) patients without (p = 0.005).
conclusionWeaning-induced pulmonary oedema was three times more frequent in case of diaphragm dysfunction. Even in case of diaphragm dysfunction, physicians might be encouraged to investigate the presence of weaning-induced pulmonary oedema during weaning failure.
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