Evidence map›Paper›PMID 34181092›Full record

ArticleAmino acids2022

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Alistair James Marsden, David R J Riley, Stefan Birkett, Quentin Rodriguez-Barucg, Barbara-Ann Guinn, Sean Carroll, Lee Ingle, Thozhukat Sathyapalan, Pedro Beltran-Alvarez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Editorial.Amino acids · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alistair James MarsdenDepartment of Biomedical Sciences, University of Hull, Cottingham Rd, Hull, HU6 7RX, UK.
David R J RileyDepartment of Biomedical Sciences, University of Hull, Cottingham Rd, Hull, HU6 7RX, UK.
Stefan BirkettDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Quentin Rodriguez-BarucgDepartment of Biomedical Sciences, University of Hull, Cottingham Rd, Hull, HU6 7RX, UK.
Barbara-Ann GuinnDepartment of Biomedical Sciences, University of Hull, Cottingham Rd, Hull, HU6 7RX, UK.
Sean CarrollDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Lee IngleDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Thozhukat SathyapalanAcademic Endocrinology, Diabetes and Metabolism, Hull York Medical School, University of Hull, Hull, UK.
Pedro Beltran-AlvarezDepartment of Biomedical Sciences, University of Hull, Cottingham Rd, Hull, HU6 7RX, UK. p.beltran-alvarez@hull.ac.uk.ORCID http://orcid.org/0000-0001-8136-8963
University of Hull · GBUniversity of Lancashire · GB

Funding

Higher Education Funding Council for England HEIFUniversity of Hull (GB) Biomarkers Research Cluster
6 · The paper itself

Abstract

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily available hair samples. Here we show, first, that human hair proteins are post-translationally modified by arginine methylation (ArgMe). Using western blot, proteomic data mining and mass spectrometry, we identify several ArgMe events in hair proteins and we show that keratin-83 is extensively modified by ArgMe in the human hair. Second, using a preliminary cohort (n = 18) of heterogenous healthy donors, we show that the levels of protein ArgMe in hair correlate with serum concentrations of a well-established cardiovascular biomarker, asymmetric dimethylarginine (ADMA). Compared to blood collection, hair sampling is cheaper, simpler, requires minimal training and carries less health and safety and ethical risks. For these reasons, developing the potential of hair protein ArgMe as clinically useful cardiovascular biomarkers through further research could be useful in future prevention and diagnosis of cardiovascular disease.

Indexed as

Cardiovascular DiseasesHairArginineBiomarkersHumansMethylationProteomicsArginineBiomarkersArginine methylation (ArgMe)Asymmetric dimethylarginine (ADMA)BiomarkerCardiovascular disease (CVD)HairPost-translational modifications (PTM)Protein

Identifiers

PMID34181092
PMCPMC9117359
OpenAlexW3173190180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.