Evidence map›Paper›PMID 34181029›Full record

ArticleArchives of toxicology2021

Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium.

Stephanie Probst, Johannes Fels, Bettina Scharner, Natascha A Wolff, Eleni Roussa, Rachel P L van Swelm, Wing-Kee Lee, Frank Thévenod

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Cadmium transport by mammalian ATP-binding cassette transporters.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  5. An Overlooked Hepcidin-Cadmium Connection.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Stephanie ProbstFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.
Johannes FelsFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.ORCID http://orcid.org/0000-0001-7731-3265
Bettina ScharnerFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.
Natascha A WolffFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.
Eleni RoussaDepartment of Molecular Embryology, Faculty of Medicine, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr. 17, 79104, Freiburg, Germany.ORCID http://orcid.org/0000-0002-0495-1597
Rachel P L van SwelmDepartment of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-6095-3258
Wing-Kee LeeFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.ORCID http://orcid.org/0000-0002-7352-4679
Frank ThévenodFaculty of Health, Institute of Physiology, Pathophysiology and Toxicology and ZBAF (Centre for Biomedical Education and Research), School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany. frank.thevenod@uni-wh.de.ORCID http://orcid.org/0000-0001-8663-3498
Witten/Herdecke University · DERadboud University Nijmegen · NLUniversity of Freiburg · DE

Funding

Bundesministerium für Bildung und Forschung 01DN16039Deutsche Forschungsgemeinschaft TH345
6 · The paper itself

Abstract

The liver hormone hepcidin regulates systemic iron homeostasis. Hepcidin is also expressed by the kidney, but exclusively in distal nephron segments. Several studies suggest hepcidin protects against kidney damage involving Fe

Indexed as

AnimalsApoptosisBinding, CompetitiveBinding SitesCadmiumCell DeathCell LineCells, CulturedDeferoxamineFemaleGene SilencingHepcidinsIronKidney Tubules, CollectingMaleMiceCadmiumDeferoxamineHamp protein, mouseHepcidinsIronReactive Oxygen SpeciesCaV3.1DFODMT1Metallothionein

Identifiers

PMID34181029
PMCPMC8298330
OpenAlexW3175160810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.