Evidence map›Paper›PMID 34180726›Full record

ArticleAIDS care2022

Barriers experienced by organ procurement organizations in implementing the HOPE act and HIV-positive organ donation.

Zachary Predmore, Brianna Doby, Debra G Bozzi, Christine Durand, Dorry Segev, Jeremy Sugarman, Aaron A R Tobian, Albert W Wu

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Efficacy of hope: Analysis of organ quality and availability among deceased HIV-positive donors.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  8. HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zachary PredmoreDepartment of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Brianna DobyPositive Rhetoric LLC, Phoenix, AZ, USA.
Debra G BozziDepartment of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Christine DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dorry SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeremy SugarmanDepartment of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Albert W WuDepartment of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USPositive Action · US

Funding

HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
NIAID NIH HHS K24 AI144954NIAID NIH HHS R01 AI120938NIAID NIH HHS U01 AI134591NIAID NIH HHS U01 AI138897
6 · The paper itself

Abstract

In the seven years since the HIV Organ Policy Equity (HOPE) Act made HIV-positive organ donation to HIV-positive recipients legally permissible in the United States, there have been fewer HIV-positive organ donations than expected. Organ procurement organizations (OPOs) play a key role in the transplant system and barriers at OPOs may be partly responsible for the relatively low number of HIV-positive donors. To understand potential OPO barriers, we conducted semi-structured interviews with 20 OPO staff members. Interviews were recorded, transcribed, and analyzed using a conventional content analytic approach with two coders. OPO staff had high levels of knowledge about HOPE. Many had evaluated referrals of HIV-positive donors and approached families for authorization. Barriers to HIV-positive organ recovery identified included obtaining authorization for donation, potentially disclosing HIV status to next-of-kin, and fear of HIV infection among those engaged in organ recovery. Strategies to overcome these barriers include providing continuing education about the specific tasks required to procure organs from HIV-positive donors, implementing targeted interventions to reduce fear of infection, and developing partnerships with HIV advocacy and care organizations. Given the central role OPOs play, HIV-positive donations are unlikely to occur in significant numbers unless these barriers can be overcome.

Indexed as

HIV InfectionsOrgan TransplantationTissue and Organ ProcurementHumansReferral and ConsultationTissue DonorsUnited StatesHIVHOPE ActOrgan procurement organizationqualitative

Identifiers

PMID34180726
PMCPMC8725194
OpenAlexW3177119532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.