Evidence map›Paper›PMID 34180716›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway.

Chen-Chung Steven Liu, Pui Wen Cheung, Anupama Dinesh, Noah Baylor, Theodor C Paunescu, Anil V Nair, Richard Bouley, Dennis Brown

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization.American journal of physiology. Cell physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Expression Regulation and Trafficking of Aquaporins.Advances in experimental medicine and biology · 2023
    Review
  7. A multiscale model of the regulation of aquaporin 2 recycling.NPJ systems biology and applications · 2022
    Article
  8. Molecular mechanisms governing aquaporin relocalisation.Biochimica et biophysica acta. Biomembranes · 2022
    Review
  9. Updates and Perspectives on Aquaporin-2 and Water Balance Disorders.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chen-Chung Steven LiuProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Pui Wen CheungProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Anupama DineshProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Noah BaylorProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Theodor C PaunescuProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Anil V NairProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Richard BouleyProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Dennis BrownProgram in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Harvard University · USMassachusetts General Hospital · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Curtis Huttenhower · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
Cell Biology of Vasopressin-induced Water Channels-Research SupplementR01DK096586 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Dennis Brown · 2012 to 2026
$7.3M
TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
Characterization of Novel Signaling Pathways Involved in Water Balance DisordersK08DK115901 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHEUNG, PUI WEN · 2018 to 2022
$919k
A Nikon A1R Confocal Microscope SystemS10RR031563 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2011 to 2011
$561k
A Zeiss LSM800 confocal microscope with AiryscanS10OD021577 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2016 to 2016
$374k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5T32DK007540HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK096586HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK115901NCRR NIH HHS S10 RR031563NIDDK NIH HHS K08 DK115901NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK096586NIDDK NIH HHS T32 DK007540NIH HHS S10 OD021577
6 · The paper itself

Abstract

The trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we show that the actin-related protein (Arp)2/3 complex, a key factor in actin filament branching and polymerization, is involved in the shuttling of AQP2 between the

Indexed as

Actin CytoskeletonActin-Related Protein 2Actin-Related Protein 3AnimalsAquaporin 2Cell MembraneEndocytosisExocytosisKidneyLLC-PK1 CellsPhosphorylationProtein TransportRatsSwineActin-Related Protein 2Actin-Related Protein 3Aquaporin 2actin-related protein 2/3aquaporin-2exocytosismembrane traffickingvesicle recycling

Identifiers

PMID34180716
PMCPMC8424666
OpenAlexW3173260847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.