Evidence map›Paper›PMID 34180713›Full record

ArticleMolecular and cellular biology2021

RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.

Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth Traxler, Mitchell J Weiss, Yoseph Barash, Stephen A Liebhaber

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Outline of Iron Metabolism, with Emphasis on Erythroid Cells.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. RNA binding proteins in cardiovascular development and disease.Current topics in developmental biology · 2024
    Article
  9. Article
  10. Post-transcriptional regulation of erythropoiesis.Blood science (Baltimore, Md.) · 2023
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Xinjun JiDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anupama JhaDepartment of Computer and Information Science, School of Engineering and Applied Science at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jesse HumenikDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Louis R GhanemGastroenterology, Hepatology and Nutrition Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Andrew KromerDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher Duncan-LewisDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Elizabeth TraxlerCell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mitchell J WeissDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Yoseph BarashDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephen A LiebhaberDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USDepartment of Physics, Mathematics and Informatics · BYSt. Jude Children's Research Hospital · US

Funding

HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Post-Transcriptional controls in Mammalian Erythroid DifferentiationR01HL065449 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIEBHABER, STEPHEN AARON · 2000 to 2019
$4.1M
Methods for RNA splicing variations detection, quantification, visualization, and association from large heterogeneous datasetsR01GM128096 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARASH, YOSEPH · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL065449NHLBI NIH HHS T32 HL007439NIGMS NIH HHS R01 GM128096
6 · The paper itself

Abstract

We previously demonstrated that the two paralogous RNA-binding proteins PCBP1 and PCBP2 are individually essential for mouse development:

Indexed as

ErythropoiesisAgingAnimalsCell LineageDNA-Binding ProteinsEmbryo, MammalianErythroid CellsExonsGenetic LociHematopoietic Stem CellsMiceRNA-Binding ProteinsRNA, MessengerRNA SplicingTranscriptomeDNA-Binding ProteinsPcbp1 protein, mousePcbp2 protein, mouseRNA-Binding ProteinsRNA, Messengerconditional gene inactivationmurine erythropoiesisPCBP1PCBP2posttranscriptional controlsRNA-binding proteins

Identifiers

PMID34180713
PMCPMC8384066
OpenAlexW3176176433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.