Evidence map›Paper›PMID 34180702›Full record

Trial reportJournal of abnormal psychology2021

Sequencing of symptom emergence in anorexia nervosa, bulimia nervosa, binge eating disorder, and purging disorder and relations of prodromal symptoms to future onset of these disorders.

Eric Stice, Christopher David Desjardins, Paul Rohde, Heather Shaw

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of abnormal psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Defining Recovery and Relapse in Bulimia Nervosa: A Systematic Review of the Literature.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Pooled it
  2. Guideline
  3. Associations Between the Use of Fitness and Diet Tracking Technology and Disordered Eating Behaviour: A Systematic Review.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Bulimia nervosa.Nature reviews. Disease primers · 2026
    Review
  8. Clinical staging for eating disorders: A scoping review and update.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Eric SticeDepartment of Psychiatry and Behavioral Sciences, Stanford University.
Christopher David DesjardinsDepartment of Mathematics and Statistics, Saint Michael's College.ORCID 0000-0002-8234-9665
Paul RohdeOregon Research Institute.ORCID 0000-0002-6869-6513
Heather ShawOregon Research Institute.ORCID 0000-0003-3210-4819
Oregon Research Institute · USSaint Michael's College · USStanford University · US

Funding

Dissonance Eating Disorder Prevention: Clinician-Led, Peer-Led, vs Web-Delivered R01MH097720 · NIMH · OREGON RESEARCH INSTITUTE · PI STICE, ERIC M · 2013 to 2017
$4.2M
Eating Disorders Prevention: An Effectiveness Trial for At-Risk College StudentsR01MH086582 · NIMH · OREGON RESEARCH INSTITUTE · PI BUTRYN, MEGHAN, STICE, ERIC M · 2010 to 2014
$2.9M
Eating Disorder Prevention Program Effectiveness TrialR01MH070699 · NIMH · OREGON RESEARCH INSTITUTE · PI STICE, ERIC M · 2005 to 2009
$1.9M
NIMH NIH HHS R01 MH070699NIMH NIH HHS R01 MH086582NIMH NIH HHS R01 MH097720
6 · The paper itself

Abstract

The objective of this study was to characterize the temporal sequencing of symptom emergence for anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), and purging disorder (PD), as well as to test whether prodromal symptoms increase risk for future onset of each type of eating disorder and compare the predictive effects to those of established risk factors. Data from four prevention trials that targeted high-risk young women with body image concerns (N = 1,952; Mage = 19.7, SD = 5.7) and collected annual diagnostic interview data over 3-year follow-up were combined to address these aims. Regarding behavioral symptoms, compensatory weight control behaviors typically emerged first for AN, BN, and PD, whereas binge eating typically emerged first for BED. Regarding cognitive symptoms, for AN, weight/shape overvaluation typically emerged first, whereas for BN, BED, and PD, overvaluation typically emerged simultaneously with feeling fat and fear of weight gain. Binge eating, compensatory behaviors, weight/shape overvaluation, fear of weight gain, and feeling fat predicted BN, BED, and PD onset, whereas weight/shape overvaluation, fear of weight gain, and lower than expected body mass index predicted AN onset. Predictive effects of prodromal symptoms were similar in magnitude to those of established risk factors: Collectively, prodromal symptoms and risk factors predicted onset of specific eating disorders with 67-83% accuracy. Results suggest that compensatory weight control behaviors and cognitive symptoms are likely to emerge before binge eating in the various eating disorders and that offering indicated prevention programs to youth with prodromal symptoms may be an effective way to prevent eating disorders. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

Prodromal SymptomsAdolescentAdultAnorexia NervosaBinge-Eating DisorderBody ImageBulimia NervosaFeeding and Eating DisordersFemaleForecastingHumansRisk FactorsYoung Adult

Identifiers

PMID34180702
PMCPMC8244173
OpenAlexW3177337946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.