Evidence map›Paper›PMID 34180593›Full record

ArticleMicrobiologyOpen2021

Thirdhand cigarette smoke leads to age-dependent and persistent alterations in the cecal microbiome of mice.

Li He, Yan-Xia Zhou, Yuqing Zhang, Bo Hang, Hang Chang, Suzaynn F Schick, Susan E Celniker, Yankai Xia, Antoine M Snijders, Jian-Hua Mao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Li HeBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yan-Xia ZhouBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yuqing ZhangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Bo HangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Hang ChangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Suzaynn F SchickDepartment of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA.
Susan E CelnikerBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yankai XiaState Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China.
Antoine M SnijdersBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-7086-1063
Jian-Hua MaoBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0001-9320-6021
Lawrence Berkeley National Laboratory · USNanjing Medical University · CNUniversity of California, San Francisco · US

Funding

Role of the gut microbiome in pesticide-induced effects on child neurodevelopmentR01ES031322 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI MAO, JIAN-HUA · 2020 to 2024
$1.4M
NIEHS NIH HHS R01 ES031322NIEHS NIH HHS R01ES031322
6 · The paper itself

Abstract

The gut microbiome composition is influenced by many factors including environmental exposures. Here, we investigated the effect of thirdhand cigarette smoke (THS) and exposure age on gut microbiome diversity. C57BL/6 mice were exposed to THS at human exposure relevant levels for three weeks during three different life stages: postnatal (0-3 weeks of age), pubescent (4-7 weeks of age), and adult (9-12 weeks of age), respectively. Cecal microbiome profiles were assessed at 17 weeks of age by 16S rRNA gene sequencing. We found that age at THS exposure strongly influenced the cecal microbiome composition. Although postnatal THS exposure significantly influenced the microbial composition, pubescent and adulthood exposures only had minor effects. The microbiome of postnatally THS-exposed mice significantly increased several degradation pathways that regulate glycolysis and pyruvate decarboxylation, and significantly decreased coenzyme A biosynthesis and pyrimidine deoxyribonucleoside salvage. Our results indicate that mouse postnatal development is particularly susceptible to persistent THS exposure effects on the gut microbiome.

Indexed as

Age FactorsAnimalsBacteriaCecumEnvironmental ExposureFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLNicotianaSmokeTobacco Smoke PollutionSmokeTobacco Smoke Pollution16S rRNA gene sequencinggut microbiomemouse exposurethirdhand cigarette smoke

Identifiers

PMID34180593
PMCPMC8123915
OpenAlexW3162892499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.