Evidence map›Paper›PMID 34180582›Full record

ArticleMicrobial biotechnology2022

CD-g-CS nanoparticles for enhanced antibiotic treatment of Staphylococcus xylosus infection.

Si-Di Zheng, Zhi-Yun Zhang, Jin-Xin Ma, Qian-Wei Qu, Bello-Onaghise God'spowe, Yue Qin, Xue-Ying Chen, L U Li, Dong-Fang Zhou, Wen-Ya Ding and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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  4. New advances into antimicrobial research.Microbial biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Si-Di ZhengCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Zhi-Yun ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Jin-Xin MaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Qian-Wei QuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Bello-Onaghise God'spoweCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Yue QinCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Xue-Ying ChenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
L U LiCollege of Life Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Dong-Fang ZhouSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Wen-Ya DingHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, Heilongjiang, 150030, China.
Yan-Hua LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.
Northeast Agricultural University · CNHeilongjiang University · CNEducation Department of Heilongjiang Province · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus xylosus (S. xylosus)-induced cow mastitis is an extremely serious clinical problem. However, antibiotic therapy does not successfully treat S. xylosus infection because these bacteria possess a strong biofilm formation ability, which significantly reduces the efficacy of antibiotic treatments. In this study, we developed ceftiofur-loaded chitosan grafted with β-cyclodextrins (CD-g-CS) nanoparticles (CT-NPs) using host-guest interaction. These positively charged nanoparticles improved bacterial internalization, thereby significantly improving the effectiveness of antibacterial treatments for planktonic S. xylosus. Moreover, CT-NPs effectively inhibited biofilm formation and eradicated mature biofilms. After mammary injection in a murine model of S. xylosus-induced mastitis, CT-NPs significantly reduced bacterial burden and alleviated inflammation, thereby achieving optimized therapeutic efficiency for S. xylosus infection. In conclusion, this treatment strategy could improve the efficiency of antibiotic therapeutics and shows great potential in the treatment of S. xylosus infections.

Indexed as

MastitisNanoparticlesStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsBiofilmsCattleFemaleHumansMiceStaphylococcusAnti-Bacterial Agents

Identifiers

PMID34180582
PMCPMC8867972
OpenAlexW3174623902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.