ArticleeLife2021
A covariation analysis reveals elements of selectivity in quorum sensing systems.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Analysis of the DNA-binding domain of thebioRxiv : the preprint server for biology · 2026Article
- RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes inJournal of bacteriology · 2026Article
- A Comprehensive Review on Various Mechanisms of Quorum Sensing Inhibition by Gold Nanoparticles.Current microbiology · 2026Review
- Exploring cooperation among social pathogens: a computational perspective.FEMS microbiology reviews · 2026Review
- Diversity and evolution of quorum-sensing systems inFrontiers in bioinformatics · 2026Article
- Review
- RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products.Microbiology resource announcements · 2025Article
- Predicting receptor-ligand pairing preferences in plant-microbe interfaces via molecular dynamics and machine learning.Computational and structural biotechnology journal · 2025Article
- A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing.Journal of bacteriology · 2023Article
- General strategies for using amino acid sequence data to guide biochemical investigation of protein function.Biochemical Society transactions · 2022Review
- Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Many bacteria communicate with kin and coordinate group behaviors through a form of cell-cell signaling called acyl-homoserine lactone (AHL) quorum sensing (QS). In these systems, a signal synthase produces an AHL to which its paired receptor selectively responds. Selectivity is fundamental to cell signaling. Despite its importance, it has been challenging to determine how this selectivity is achieved and how AHL QS systems evolve and diversify. We hypothesized that we could use covariation within the protein sequences of AHL synthases and receptors to identify selectivity residues. We began by identifying about 6000 unique synthase-receptor pairs. We then used the protein sequences of these pairs to identify covariation patterns and mapped the patterns onto the LasI/R system from
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Registered trials
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