Evidence map›Paper›PMID 34180394›Full record

ArticleeLife2021

Global constraints within the developmental program of the

Vasyl Alba, James E Carthew, Richard W Carthew, Madhav Mani

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Bridging developmental and statistical approaches to variation and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Searching for physical principles of morphogenesis.Development (Cambridge, England) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Utilizing developmental dynamics for evolutionary prediction and control.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Developmental bias predicts 60 million years of wing shape evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vasyl AlbaDepartment of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, United States.
James E CarthewDepartment of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, United States.
Richard W CarthewNSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, United States.ORCID 0000-0003-0343-0156
Madhav ManiDepartment of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, United States.ORCID 0000-0002-5812-4167
Northwestern University · US

Funding

YEAST ER MOLECULAR CHAPERONE TRANSLOCATION: GENOME DATABANK HOMOLOGSP41RR006009 · NCRR · MELLON PITTS CORPORATION (MPC CORP) · PI KNOLL, ERIC · 1990 to 2011
$22.0M
Non-coding RNAs and their mechanisms and functions-RenewalR35GM118144 · NIGMS · NORTHWESTERN UNIVERSITY · PI Richard W. CARTHEW · 2016 to 2026
$6.8M
National Science Foundation 1547394National Science Foundation 1764421NCRR NIH HHS P41 RR006009NIGMS NIH HHS R35 GM118144Simons Foundation 597491
6 · The paper itself

Abstract

Organismal development is a complex process, involving a vast number of molecular constituents interacting on multiple spatio-temporal scales in the formation of intricate body structures. Despite this complexity, development is remarkably reproducible and displays tolerance to both genetic and environmental perturbations. This robustness implies the existence of hidden simplicities in developmental programs. Here, using the

Indexed as

Biological Variation, PopulationPhenotypeAnimalsDrosophila melanogasterWings, Animaldevelopmental biologyD. melanogasterevolvabilitymorphometricsphysics of living systemsrobustness

Identifiers

PMID34180394
PMCPMC8257256
OpenAlexW3174771785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.