ArticleAnnals of neurology2021
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache.
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.The journal of headache and pain · 2026Pooled it
- Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor.Annals of neurology · 2023Pooled it
- Circadian Features of Cluster Headache and Migraine: A Systematic Review, Meta-analysis, and Genetic Analysis.Neurology · 2023Pooled it
- Risk and reward seeking behaviour in episodic cluster headache - a psychometric and behavioural study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Reviewing the complex relationship between circadian rhythms and cluster headache.Cephalalgia : an international journal of headache · 2025Review
- Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.Scientific reports · 2025Article
- 15. Cluster Headache.Pain practice : the official journal of World Institute of Pain · 2025Review
- Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors.Communications biology · 2024Article
- MERTK in the rat trigeminal system: a potential novel target for cluster headache?The journal of headache and pain · 2024Article
- Analysis of weighted gene co-expression networks and clinical validation identify hub genes and immune cell infiltration in the endometrial cells of patients with recurrent implantation failure.Frontiers in genetics · 2024Article
- Alterations in DNA methylation associate with reduced migraine and headache days after medication withdrawal treatment in chronic migraine patients: a longitudinal study.Clinical epigenetics · 2023Article
- Review
- Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.Journal of neurology · 2023Article
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Debate: Are cluster headache and migraine distinct headache disorders?The journal of headache and pain · 2022Review
- Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan.The journal of headache and pain · 2022Article
- Cluster Analysis Revealed Two Hidden Phenotypes of Cluster Headache.Frontiers in neurology · 2022Article
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Authors and funding
23 authors at 7 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIdentifying common genetic variants that confer genetic risk for cluster headache.
methodsWe conducted a case-control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.
resultsAn association was found with cluster headache for 4 independent loci (r
interpretationThis genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203-216.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.